Poly(2'-O-methyladenylic acid) [poly(Am)] inhibited tumor development and death induced by the Moloney sarcoma virus-leukemia virus complex in newborn mice. The compound was effective at 10 mug per mouse when given at least 1 hr before inoculation of virus, but the greatest inhibition was seen in mice treated at least 4 hr before infection. Poly(2'-O-methyluridylic acid) and poly(vinyladenine) ...

The human infant is delivered at a stage in which every organ system is very much in the process of rapid development. As such, this stage of life is unique relative to any other that the organism will subsequently experience. This Research Topic focuses on the immune system of the newborn as one such organ system. The articles herein are original research or review articles that discuss some a...

Maternal effects by which females provide their offspring with non-genetic factors such as hormones, nutrients and antibodies can have an important impact on offspring fitness. In vertebrates, maternal antibodies (matAb) are transferred from the mother, via the placenta, egg yolk or milk during lactation to offspring until they are 2 weeks (birds), 4-10 weeks (rodents) and 9 months (humans) old...

Autosensitization of rat or mouse lymphoid cells against syngeneic fibroblast antigens was induced in cell culture. Rat lymphoid cells autosensitized by this method were able to produce immunospecific lysis of syngeneic target fibroblasts in vitro or GvH reactions in newborn rats. Autosensitized mouse spleen cells mediated similar GvH reactions when injected into newborn mice. The nature of the...

The potential for vaccines to act as triggers of autoimmune reactions has received much recent attention. Such an association is very poorly defined mechanistically, but may potentially involve epitope mimicry between vaccinal and self antigen, or the immuno-stimulatory effects of vaccine adjuvant. If such reactions occur, they are more likely to involve adults than infants in early life, as a ...

micrornas (mirnas) are small preserved non-coding rna molecules that regulate gene expression post-transcriptionally by targeting the 3' utr of mrnas for translational repression or degradation. the rising evidence has established the significant role of mirnas within the regulation of immune system and the prevention of autoimmunity. mir-146a has obtained an importance as a modulator of d...

the effects of methanolic extract and leaf powder of artemisia annua were studied on performance, cellular and humoral immunity in 240 cobb broiler chicks in a completely randomized design. control group did not receive any treatment. the chicks in the second and third groups were fed with feed which contained 2000 and 4000 ppm plant extract in diet and in the groups 4, 5 and 6 chicks received ...

objectives: the aim of the present study was to investigate immunotoxic effect of safranal (saf), a main component of crocus sativus essential oil, using balb/c mice. materials and methods: saf was administered intraperitoneally at doses of 0.1, 0.5 and 1 ml/kg for 3 weeks. hystopathological examination of spleen and bone marrow, cellularity of spleen, delayed type of hypersensitivity (dth) res...

Cell-mediated immunity and T-lymphocyte maturation are impaired in HIV-infected children. These abnormalities would be detected in HIV-uninfected offspring of HIV women (seroreverters [SR]) if HIV or its soluble proteins could cross the placental barrier. Immunophenotypic analyses were performed in 20 healthy HIV-uninfected newborns of HIV-infected mothers (SR), and in 14 healthy newborns of HI...