Redox-active drugs are the mainstay of parasite chemotherapy. To assess their repurposing potential for eumycetoma, we have tested a set nitroheterocycles and peroxides in vitro against two isolates Madurella mycetomatis, main causative agent eumycetoma Sudan. All compounds were inactive except niclosamide, which had minimal inhibitory concentrations around 1 µg/mL. Further tests with niclosami...

Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron loss in the brain and spinal cord; however, its etiology unknown, no curative treatment exists. TAR DNA-binding protein 43 (TDP-43), encoded TARDBP, a genetic mutation observed 2–5% of familial ALS, TDP known to be mislocalized cytoplasm. This study aimed identify compounds that inhibited nuclear cytoplasmic locali...

Controlling COVID-19 requires therapy and continued vaccination. Long-acting therapeutics offer options for test-and-cure strategies overcome poor adherence. Extended in vivo niclosamide exposure is demonstrated here as such a candidate.

The primary cause of death from breast cancer is the progressive growth of tumors and resistance to conventional therapies. It is currently believed that recurrent cancer is repopulated according to a recently proposed cancer stem cell hypothesis. New therapeutic strategies that specifically target cancer stem-like cells may represent a new avenue of cancer therapy. We aimed to discover novel c...

Niclosamide is classified under World Health Organization's crucial medicines and it categorized as an anthelmintic drug to target tapeworm infections. In recent findings successfully repurposed a multifunctional effective against many diseases. The approach for synthesis of niclosamide very crisp, simple affordable. Besides these outstanding activities easy method synthesis, the poor solubilit...

We report a case of Hymenolepis diminuta infection in an Italian child affected by tuberous sclerosis. Praziquantel is the drug of choice for the treatment of H. diminuta infection. However, considering the patient's neurological disease, we decided to use not praziquantel but niclosamide, which proved equally effective.

The freshwater snail Oncomelania hupensis is the only intermediate host of Schistosoma japonicum, which causes schistosomiasis. This disease is endemic in the Far East, especially in mainland China. Because niclosamide is the only molluscicide recommended by the World Health Organization, 50% wettable powder of niclosamide ethanolamine salt (WPN), the only chemical molluscicide available in Chi...

BACKGROUND Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. Addressing the therapeutic potential of modulating mTORC1 signaling and autophagy in human disease requires active chemicals with pharmacologically ...