Nicotinic acid adenine dinucleotide phosphate represents a newly identified second messenger in T cells involved in antigen receptor-mediated calcium signalling. Its function in vivo is, however, unknown due to the lack of biocompatible inhibitors. Using a recently developed inhibitor, we explored the role of nicotinic acid adenine dinucleotide phosphate in autoreactive effector T cells during ...

The investigations of Starr (1) demonstrated that Xunthomonas pruni requires an exogenous source of nicotinic acid when grown on a medium containing vitamin-free, acid-hydrolyzed casein, methionine, or glutamic acid to provide an organic form of nitrogen. Preliminary work in this laboratory showed that tryptophan could replace nicotinic acid for growth in a similar medium. This was the first kn...

The cholera enterotoxin produces intestinal secretion associated with an elevation of tissue levels of cyclic adenosine 3',5'-monophosphate levels of cyclic adenosine 3',5'-monosphosphate (cAMP). The objectives of this study were to determine whether intestinal secretion and cAMP elevation induced by cholera toxin could be prevented, or once initiated, reversed by nicotinic acid, an agent known...

Previous studies from our laboratory indicated that the initial step in the biosynthesis of nicotinamide adenine dinucleotide from nicotinamide in mammalian liver involves the enzymatic deamidation of nicotinamide to nicotinic acid (1, 2). The nicotinic acid is then converted to NAD via the pathway described by Preiss and Handler, involving the intermediate formation of nicotinic acid mononucle...

AVhen the identification of pellagra-preventive factor with nicotinic acid, and the therapeutic value of nicotinic acid and its amide in the treatment of pellagra became established, it was desirable to devise methods for their quantitative determination in urine, in order to provide useful information in clinical investigations and for assessing the level of nutrition with respect to nicotinic...

A simple, precise and cost effective spectrophotometric method have been developed for the estimation Atorvastatin and Nicotinic acid in combination in tablet dosage form by UV spectroscopy, using multi-component mode of analysis. Methanol used as solvent λmax of Atorvastatin and Nicotinic acid was found to be 248nm and 261.5nm respectively. The method shows linearity in the Atorvastatin and Ni...

This paper will focus on the use of nicotinic acid as a therapeutic option for cardiovascular risk reduction in patients with abnormal glucose metabolism and ‘atherogenic dyslipidaemia’. This is characterised by low levels of HDL-C, high triglycerides, and preponderance of small, dense LDL particles. Whilst nicotinic acid may increase plasma glucose in some patients, more recent studies show th...

Nicotinic acid has been used clinically for over 40 years in the treatment of dyslipidemia producing a desirable normalization of a range of cardiovascular risk factors, including a marked elevation of high density lipoprotein and a reduction in mortality. The precise mechanism of action of nicotinic acid is unknown, although it is believed that activation of a G(i)-G protein-coupled receptor m...

The recent discovery of the G(i) protein-coupled receptor GPR109A (HM74A in humans; PUMA-G in mice) as a receptor for nicotinic acid has provided the opportunity to gain greater understanding of the underlying biology contributing to the clinical efficacy (increases in HDL, decreases in VLDL, LDL, and triglycerides) and the characteristic side-effect profile of nicotinic acid. GPR109A has been ...

Dear Editor, Nicotinamide with tetracycline or doxycycline is used in the treatment of bullous pemphigoid. Nicotinamide is used in doses of 1500 to 2000 mg/day in divided doses in these cases. Nicotinic acid/laropiprant (Tredaptive®) is a lipid lowering agent which contains 1000 mg of nicotinic acid (niacin) and 20 mg of laropiprant which is a selective antagonist of prostaglandin D2 receptor. ...