BACKGROUND Cyclooxygenase 2 inhibition has proven analgesic efficacy in a variety of surgical procedures. We postulated that perioperative cyclooxygenase 2 inhibition significantly reduces postoperative morphine requirements after major thoracic surgery and investigated the site of this potential analgesic effect. METHODS Ninety-two patients participated in this single-center, double-blind, r...

Nimesulide, a COX-2 selective drug, possesses anti-inflammatory and analgesic properties. Moreover, it has low gastrointestinal and renal toxicity. This paper presents industrially viable, new and improved synthesis of nimesulide starting from o-chloro nitrobenzene. The reaction with triphenyl phosphate yields 2-phenoxy nitrobenzene (90%) followed by reduction and mesylation and finally selecti...

Nitric oxide (NO) and prostaglandins are inflammatory mediators produced during meningitis. The purpose of the present study was to pharmacologically inhibit cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) to 1) explore the prostaglandin contribution to blood-cerebrospinal fluid barrier permeability alterations and 2) elucidate the in vivo concentration relationship between prostaglan...

BACKGROUND Neuropathic pain is a chronic pain due to disorder in the peripheral or central nervous system with different pathophysiological mechanisms. Current treatments are not effective. Analgesic drugs combined can reduce pain intensity and side effects. Here, we studied the analgesic effect of nimesulide, nefopam, and morphine with different mechanisms of action alone and in combination wi...

The spectrophotometric methods of determination the active pharmaceutical ingredients meloxicam and nimesulide were reviewed a simple UV-spectrophotometric method for these in industrial equipment cleaning validation samples was proposed. based on extraction residual quantities from manufacturing surface by concentrated sodium carbonate solution subsequent basic forms drugs at wavelength 362 nm...

The aim of the work was to identify anti-inflammatory effect a newly synthesized drug from group 4-thiazolidinones. Thus, comparative study two agents conducted: Les6490 and non-steroidal nimesulide. This belongs drugs (NSAIDs), which have pronounced anti-inflammatory, analgesic antipyretic effects. Nimesulide highly selective inhibitors cyclooxygenase its isoenzymes (COX-2) is used for treatme...

Objective: Assessment of pain and analgesic efficacy can be made after extraction of a mandibular third molar. The objective of this study is to determine the effect of preemptive administration of nimesulide, metamizole sodium and placebo on the intensity of postoperative pain after extraction of impacted mandibular third molars. Study Design: This is a randomized, double-blind, placebo-contro...

Nimesulide is a non-steroidal anti-inflammatory drug that acts through selective inhibition of COX-2 enzyme. Poor bioavailability of this drug may leads to local toxicity at the site of aggregation and hinders reaching desired therapeutic effects. This study aimed at formulating and optimizing topically applied lotions of nimesulide using an experimental design approach, namely response surface...

Several studies point to an important function of cyclooxygenase (COX) and prostaglandin signaling in models of synaptic plasticity which is associated with N-methyl-D-aspartate receptors (NMDARs). Cyclooxygenase gene is suggested to be an immediate early gene that is tightly regulated in neurons by NMDA dependent synaptic activity. Nonsteroid Antiinflammatory Drugs (NSAIDs) exert their antiinf...