Nowdays, the design of the optimalniosomal formulation may ensure the best performance in terms of physico-chemical properties and drug skin permeation. Our study want to propose the loading of Tetracycline or Tetracycline hydrocholoride drugs as strategy to modulate niosomes properties, with particular emphasis on encapsulation and percutaneous permeation behavior. Niosomes were prepared from ...

The present study was designed to develop and compare acyclovir containing nano-vesicular liposomes and niosomes based on cholesterol, soya L-alpha-lecithin and nonionic surfactant, span 20. The effort was made to study in vitro whether acyclovir-loaded nanovesicles could sustain the release of the drug by increasing residence time and thus, acyclovir could reduce its dose-related systemic toxi...

Topical beta-blocking agents are nowadays the drugs of choice as these have few ocular and systemic side effects. In the present study some selected beta blockers (PP-24, PP-34, PP-41, PP-48, PP-50), synthesized using 4-hydroxybenzaldehyde and isovanillin were encapsulated into niosomes possessing a high drug entrapment efficiency in order to be used as ophthalmic carriers for topical ocular tr...

Niosomes are vesicular nacarriers that can be used for both amphiphilic and lipophilic drugs. budding vehicles in advanced drug delivery systems. nionic surfactants vesicles formed with or without the addition of cholesterol. best choice because their specific characters like biodegradability, biocompatibility, immugenic nature. easily trap hydrophilic drugs extend period systemic circulation. ...

In this study, different positively charged niosomal formulations containing sorbitan esters, cholesterol and cetyl trimethyl ammonium bromide were prepared by film hydration method for the entrapment of autoclaved Leishmania major (ALM). Size distribution pattern and stability of niosomes were investigated by laser light scattering method and ALM encapsulation per cent was measured by the bici...

BACKGROUND/AIM The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. MATERIALS AND METHODS Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for p...

A novel oral drug delivery system, TPGS modified docetaxel proniosomes (DTX-TPGS-PNs), was designed to enhance the oral bioavailability and antitumor efficiency of the poorly water-soluble drug docetaxel. DTX-TPGS-PN niosomes were 93 ± 6.5 nm in size, -18.53 ± 1.65 mV in zeta potential and exhibited spherical morphology, with an encapsulation efficiency of 97.31 ± 0.60%. The system showed susta...

Our previous study demonstrated the potent in vitro collagen biosynthesis stimulating and antioxidant activities of Volvariella volvacea extract. This study was performed the loading of V. volvacea extract (VV) in niosomes (NV). The physicochemical characterization of the VV loaded niosomes and gel containing niosome of the extract (GNV) was studied. Rat skin transdermal absorption by Franz dif...

Over the past years the treatments of disease have undergone a revolutionary change. With the advancement of pharmaceutical science not only novel drug delivery system have been developed but also emphasis has been laid to deliver the active constituent to the diseased site.The basic component of such a system is a suitable carrier that protects the active medicament from degradation or clearan...