objective(s) celecoxib acts through both cox-2-dependent and -independent pathways. according to the paradoxical effect of no on the inflammatory and nociceptive signal processing, the present study designed to evaluate the probable contribution of no in the analgesic and anti-inflammatory properties of celecoxib. materials and methods different intensities of inflammatory pain were induced by ...

introduction: response to morphine and role of nitric oxide (no) on expression of morphine response has been studied in vertebrates. but, little evidence is provided in the matter in earlier invertebrates. this investigation for the first time evaluated the effect of no on expression of morphine potency in paramecium caudatum. methods: animal after isolation from natural media and specific iden...

diagnosis of subclinical and early stage clinical periodontal dysfunction could prevent from further socioeconomic burden. the aim of this study was to assess the diagnostic applicability of nitric oxide and its end-metabolites in periodontal tissue health and disease. forty-two patients were enrolled and divided into three groups according to gingivitis (gi) and clinical attachment level (cal)...

this experiment was conducted to evaluate the effects of supplemental l-arginine (arg) in reduced-protein diets on cardiopulmonary performance and intestinal morphology in the broilers reared at high altitude. a total of 156 day-old male broilers were randomly assigned to 3 treatments and 4 replicates of 13 chicks and reared up to 42 days of age. treatment groups were designed as a normal-prote...

12 13 The removal of fluoride using red mud has been improved by acidifying red mud with 14 hydrochloric, nitric and sulphuric acid. This investigation shows that the removal of fluoride 15 using red mud is significantly improved if red mud is initially acidified. The acidification of 16 red mud causes sodalite and cancrinite phases to dissociate, confirmed by the release of 17 sodium and alumi...

objective(s):the neuropeptide calcitonin gene-related peptide (cgrp) has long been postulated to play an integral role in the pathophysiology of migraine. earlier studies showed that cgrp can stimulate the synthesis and release of nitric oxide (no) and cytokines from trigeminal ganglion glial cells. the purpose of this study was to determine the effect of 17β-estradiol in regulation of cgrp exp...

Nitric oxide has been found to play an important role as a signal molecule in many parts of the organism as well as a cytotocic effector molecule of nonspecific immune response. Nitric oxide is very important functions both in helminthes and mammalian hosts. Nitric oxide may react with proteins and nucleic acids. In addition to binding to heme groups, e.g. of guanylate cyclase, hemoglobin, and ...

Tsutsui, Masato, Hisashi Onoue, Yasuhiko Iida, Leslie Smith, Timothy O’Brien, and Zvonimir S. Katusic. Effects of recombinant eNOS gene expression on reactivity of small cerebral arteries. Am. J. Physiol. Heart Circ. Physiol. 278: H420–H427, 2000.—Resistance arteries are an important target for vascular gene therapy because they play a key role in the regulation of tissue blood flow. The presen...

Striatin is a protein regulator of vesicular trafficking in neurons that also binds caveolin-1 and Ca(2+)-calmodulin and could activate endothelial nitric oxide synthase. We have shown that striatin colocalizes with the mineralocorticoid receptor and that mineralocorticoid receptor activation increases striatin levels in vascular cells. To test whether striatin is a regulator of vascular functi...

Introduction: The relation between morphine and nitric oxide release has been shown. Due to important role of nitric oxide in regulation of skin blood flow, the aim of this study was to investigate the effect of nitric oxide synthase inhibitor (L-NAME) and nitric oxide synthesis precursor (L-arginine) on skin blood flow of intact and morphine-dependent rats. Methods: Skin blood flow of hind pa...