Nitric oxide (NO) is involved in several biological processes, but its role in human melanogenesis is still not well understood. Exposure to UVA and UVB induces nitric oxide production in keratinocytes and melanocytes through the activation of constitutive nitric oxide synthase, increasing tyrosinase activity and melanin synthesis, whereas inducible nitric oxide synthase over expression might b...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inos inhibitor on spatial memory, in anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials of animals were conducted. spatial mem...

The objective of the study is to find out whether the endothelial nitric oxide synthase (eNOS) G894T single-nucleotide polymorphism is associated with type 2 diabetes mellitus in South Indian (Tamil) population. A total number of 260 subjects comprising 100 type 2 diabetic mellitus patients and 160 healthy individuals with no documented history of diabetes were included for the study. DNA was i...

The identification of human inflammatory cells that express inducible nitric oxide synthase and the clarification of the role of inducible nitric oxide synthase in human infectious or inflammatory processes have been elusive. In neutrophil-enriched fractions from urine, we demonstrate a 43-fold increase in nitric oxide synthase activity in patients with urinary tract infections compared with th...

AIMS To evaluate the role of nitric oxide, reactive oxygen species (ROS), and natriuretic peptide receptor-B activation in C-type natriuretic peptide-anti-contractile effect on Phenylephrine-induced contraction in aorta isolated from septic rats. METHODS AND RESULTS Cecal ligation and puncture (CLP) surgery was used to induce sepsis in male rats. Vascular reactivity was conducted in rat aorta...

Recent studies [3] revealed that both nitric oxide (NO) synthase (NOS) isoforms NOS I and NOS II in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located [18], are tonically active under physiologic conditions. The prevalence of NOS I over NOS II activity at the RVLM and the associated dominance of sympathoexcitation over sympathoinhibition may underlie the ma...

BACKGROUND Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. METHODS We examined whether endothelial...

BH4: Tetrahydrobiopterin; BH2: Dihydrobiopterin; NOS: Nitric Oxide Synthase; eNOS: endothelial Noxide Synthase; nNOS: Neuronal Nitric Oxide Synthase; iNOS: Inducible Nitric Oxide Synthase; CAD: Coronary Artery Disease; LC-MS/MS: Liquid Chromatography and Tandem Mass Spectrometry; GTCH1: Guanine Triphosphate Cyclohydrolase; NOS3: Nitrous Oxide Synthase 3 – Endothelial; QDPR: Quinoid Dihydropteri...

Immunosuppressants FK506 and cyclosporin A inhibit neurotoxicity of N-methyl-D-aspartate in primary cortical cultures, while having no effect on quisqualate- and kainate-mediated neurotoxicity. Rapamycin completely reverses the neuroprotective effect of FK506. Both FK506 and cyclosporin A inhibit NMDA-elicited/nitric oxide-mediated increases in cGMP levels in cortical cultures. FK506 has no eff...

BACKGROUND Endothelial nitric oxide synthase produces nitric oxide which is involved in many physiologic regulatory functions. Variable number of tandem repeats in intron 4 of endothelial nitric oxide synthase gene are reported to be associated with blood pressure regulation. Nitric oxide is involved in regulation of cardiomyocyte genes but it is not known If endothelial nitric oxide synthase 4...