Bacterial vaginosis (non-specific vaginitis) is a mild but common condition. O'Dowd et al reported that organisms associated with vaginosis could be isolated from 37% of women who presented with vaginal symptoms. The current treatment of choice is an oral nitroimidazole (metronidazole or tinidazole), given either as a single large dose or as a twice daily regimen for five to seven days. A probl...

A total of 32 drugs were evaluated as regards their efficacy for oral treatment of Ichthyobodo necator infestation of rainbow trout. In preliminary trials, all drugs were supplied to infected fish at 40 g per kg of feed for 10 d. The majority of the drugs tested (1,3-di-6-quinolylurea, aminosidine, amprolium, benznidazole, bithionol, chloroquine, diethylcarbamazine, dimetridazole, diminazene ac...

A number of mono and bicyclic nitroimidazoles were screened for in vitro antileishmanial activity. Among these, compounds belonging to the class of nitroimidazo[2,1-b]oxazoles showed moderate to good activity. This class of compounds had been reported previously to have pronounced antitubercular activity, particularly CGI17341 (5a). In the present study (5a) and (5d) and (7) were found to be mo...

Starting from 2-(2-pyridyl) imidazole a series of substituted imidazoles (2-5) were prepared. From the reaction of 2-(3-pyridyl) -4-(or 5) nitroimidazole (15) with dimethyl sulfate in alkaline medium 1-methyl-2-(3- pyridy1)-4-nitroimidazole (6,)w as prepared. Reaction of compound 15 with diazomethane gave I-methyl-2-(3-pyridy1)-5- nitroimidazol(e7 ) in addition to 6. The antibacterial and an...

A new anti-protozoal compound, ornidazole, a derivative of nitroimidazole, was given in a single 2 g dose to 20 women with Trichomonas vaginalis infection. All the women were cured, but they suffered some side-effects. Plasma levels of ornidazole reached a peak five to eight times higher than minimum inhibitory concentrations and exceeded this level for at least 36 hours. It is therefore possib...

Two substituted quinazolinyl/imidazolyl-salicylic acids 5, 6 were synthesized by the reaction of 6-iodo-2-methylbenzoxazin-4-one/5-nitroimidazole with 5-aminosalicylic acid (5-ASA). Coupling of compounds 5 and 6 with different amino acid ester hydrochlorides, dipeptide and tripeptide methyl esters yielded novel quinazolino/imidazolopeptide derivatives 5a-f and 6a-g. The chemical structures of a...

With the aim of determining the actual target(s) of nitro-group bearing compounds considered as possible leads for the development of drugs against Chagas' disease, we studied in parallel nitrofurans and nitroimidazoles. We investigated nine representative compounds for the following properties: efficacy on different Trypanosoma cruzi strains, redox cyclers, inhibition of respiration, productio...