Chimeric antigen receptor (CAR)-modified immune cell therapy has become an emerging treatment for cancers and infectious diseases. NK-based immunotherapy, particularly CAR-NK cell, is one of the most promising 'off-the-shelf' development without severe life-threatening toxicity. However, bottleneck developing a successful achieving sufficient numbers non-exhaustive, long-lived, cells from third...

Introduction: Extranodal Natural Killer (NK)/T-cell lymphoma (NKTCL) nasal type is a rare but well-known disease with poor prognosis. NKTCL is more prevalent in Asia and comprises about 7-10% of all non-Hodgkin lymphoma cases in this region. The characteristic clinical pattern of NKTCL is the destruction of the midline structures of the mid-face. Case Report: The present study examines a case o...

Background: Lenalidomide, a synthetic immunomodulatory drug, has a wide range of features including anti-angiogenic and anti-proliferative properties. To date, researchers have shown that lenalidomide is capable of ameliorating the immune system factors and antitumor responses. Most researchers have reported that lenalidomide enhances the immune response in certain cancer patients through sever...

Increasing knowledge of cancer immunology has led to the design therapies using immune cells directly or manipulating their activity, collectively termed immunotherapy. In field immuno-oncology, research on adaptive T development CAR-T cells. Innate such as NK can also eliminate oncogenically transformed and regulate system. Considering a live drug, numerous methods for isolation activation hav...

Abstract NK cells mediate anti-leukemic immunosurveillance in AML. We hypothesized that impaired predict poor outcomes analyzed the expression of receptors on CD56 cell subsets and their corresponding ligands CD45dim blast by flow cytometry 100 AML 17 healthy bone marrows. Risk stratification, complete remission, relapse, measurable residual disease, overall survival, relapse-free ligand expres...

background: infertility is an increasing medical and social problem. in vitro fertilization (ivf) has become a common and accessible treatment for a wide variety of indications that have variable outcomes. natural killer (nk) cells have been identified as relevant immunological factors involved in reproductive success or failure. objective: the aim of this study was to compare the percentage of...

Development of natural killer (NK) cells is thought to depend on interactions between NK progenitors and the bone marrow (BM) microenvironment; however, little is known about the molecular signals involved. Here we show that lymphotoxin (LT) provides an important signal for the development of both NK cells and NK/T cells. LTalpha-/- mice show marked reduction in splenic and BM NK and NK/T cell ...

Background: Natural killer (NK) cells originate from the differentiation of hematopoietic stem (HSCs) in common lymphoid progenitor pathway, and HSCs can be obtained umbilical cord blood (UCB). Comparative studies NK cell between cultured freshly isolated are important development therapy for cancer. This study aimed to compare maturation stages newly HSC samples using interleukin-2 absence fee...