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Fanconi Anemia (FA) is an autosomal recessive syndrome characterized by congenital abnormalities, progressive bone marrow failure, and susceptibility to cancer. FA has eight known complementation groups and is caused by mutations in at least seven genes. Biallelic BRCA2 mutations were shown recently to cause FA-D1. Monoallelic (heterozygous) BRCA2 mutations confer a high risk of breast cancer a...
BACKGROUND AND PURPOSE Professional boxing may result in brain injury. We hypothesize that quantitative MR diffusion imaging may be useful in determining early white matter changes. METHODS Forty-nine professional boxers (age 30 +/- 4.5 years) and 19 healthy control subjects (age 32 +/- 9.5 years) were imaged on a clinical 1.5T scanner. None of the subjects had neurologic disorder or deficit....
Abstract Food addiction (FA) is characterized by poorly controlled intake of highly-palatable, calorically-dense, high-sugar, high-fat, and usually processed foods. Although not existing in the DSM-5 or ICD, it has been a widely discussed clinical research entity for more than decade, understanding both obesity also disordered eating behaviours. Most studies indicate that risk factors FA are si...
In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: ...
Fanconi anemia (FA) is characterized by chromosome fragility, bone marrow failure (BMF) and predisposition to cancer. As reverse genetic mosaicism has been described as “natural gene therapy” in patients with FA, we sought evaluate the clinical course of a cohort FA mosaic followed at referral centers Spain over 30-year period. This includes majority T cells without chromosomal aberrations DEB-...
BACKGROUND Fibrosing alveolitis (FA) is a common and serious complication of rheumatoid arthritis (RA). Before the availability of high resolution computed tomographic (HRCT) scanning, it was difficult to diagnose accurately without recourse to biopsy. Prospective studies have reported a prevalence of interstitial lung disease (ILD) of 19-44%. The term ILD used by these authors encompasses a va...
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