background: there is no published data on the association between serum biochemical and ultrasonographic markers and adverse pregnancy outcomes. therefore, the aim of this study was to determine the factors associated with perinatal outcomes in singleton pregnancies using ultrasound and maternal serum markers during the first trimester in panamanians. materials and methods: this was a prospecti...

introduction: the purpose of the screening of fetal anomalies in pregnancy is empowering women to make an informed choice and reduce uncertainty in decision making. on the other hand, screening may cause worry and anxiety in pregnant women. this study was conducted with aim to determine the relationship between informed choice in pregnant women about screening of fetal anomalies with worry and ...

Current prenatal diagnosis for fetal aneuploidies (including trisomy 21 [T21]) generally relies on an initial biochemical serum-based noninvasive prenatal testing (NIPT) after which women who are deemed to be at high risk are offered an invasive confirmatory test (amniocentesis or chorionic villi sampling for a fetal karyotype), which is associated with a risk of fetal miscarriage. Recently, ge...

To analyze the characters of Down syndrome (DS) who failed to be diagnosed after prenatal screening and hope to be able to improve the programs of prenatal screening and reduce the missed diagnosis of DS. In this multicenter study, we collected the missed cases from 3 prenatal diagnosis centers and analyzed their characters. A total of 126 DS babies failed to be diagnosed after prenatal screeni...