This article discusses selected “rewritings” of Edward Lear’s nonsense poem “The Akond Swat”, focusing specifically on the translators’, illustrators’, adapters’ and editors’ attitudes towards allusive nature – reference it makes to historical figure Pashtun religious leader Abdul Ghaffūr, also known as (or Wali) Swat or Saidū Bābā, which may be viewed orientalist parodistic from a contemporary...

Making Sense of Nonsense: Readings Children’s Poetry as Play and Creative Thinking
 Abstract: Nonsense meaning are not necessarily conflicting concepts, but can be conceived a hendiadys, that is, opposites, the one or other, other. The idea nonsense related coexist is premise for this article, which describes different structures in poetry Birgitte Krogsbøll Kamilla Wichmann’s picture book...

Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass therapy (TBT). Initial results demonstrate the need for more potent drugs and an in vivo model system for quantitative assessment of TBT. Herein, we present an in vivo system for evaluating the efficacy of premature stop codon management therapies: in vivo quantitative stop codon management repl...

Nonsense SNPs introduce premature termination codons into genes and can result in the absence of a gene product or in a truncated and potentially harmful protein, so they are often considered disadvantageous and are associated with disease susceptibility. As such, we might expect the disrupted allele to be rare and, in healthy people, observed only in a heterozygous state. However, some, like t...

The effect of deletion of the operator-distal genes of the trp operon, including the trpE-trpD intercistronic punctuation point, on the degree of transcriptional polarity (in this case the effect of a nonsense mutation on the level of mRNA from the distal part of the very gene where the mutation is located) was investigated. Double mutants which contain a nonsense mutation and a deletion in trp...

Nonsense mutations leading to premature stop codons are common occurring in approximately 12% of all human genetic diseases. Thus, pharmacological nonsense mutation suppression strategies would be beneficial to a large number of patients if the drugs could be targeted to the affected tissues at the appropriate time. Here, we used nonsense suppression to manipulate Pax6 dosage at different devel...

In a screen for suppressors of the Drosophila wingless(PE4) nonsense allele, we isolated mutations in the two components that form eukaryotic release factor. eRF1 and eRF3 comprise the translation termination complex that recognizes stop codons and catalyzes the release of nascent polypeptide chains from ribosomes. Mutations disrupting the Drosophila eRF1 and eRF3 show a strong maternal-effect ...