Benincasa hispida Cogn. (Cucurbitaceae) commonly known as wax gourd (1) is an important ingredient of kushmanda lehyam, an Ayurvedic medicine widely used as rejuvenative agent (Rasayana) in treatment of epilepsy and other nervous disorders (2). In Ayurvedic system of medicine, Benincasa hispida fruits are used for treatment of schizophrenia and other psychologic disorders (3). Methanolic extrac...

The interaction of NMDA receptor (NMDAR) activation and other mechanisms regulating neuronal excitability have not been thoroughly described. While excess activation of NMDARs results in excitotoxicity, partial activation of NMDARs by d-cycloserine (DCS) is nootropic, enhancing both acquisition and extinction of memories. The mechanism by which DCS treatment enhances memory is unclear. NMDAR ac...

Nootropic activity of leaves of Prunella vulgaris was studied in mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg/kg, i.p.) was used to induce amnesia in mice. The ethanolic extracts of leaves of Prunella vulgaris PV (50 and 100 mg/kg, p.o.) significantly attenuated amnesic deficits induced by scopolamine (0.4 ...

agent technology is an emerging and promising research area in software technology, which increasingly contributes to the development of value-added information systems for large healthcare organizations due to its capability to automatically modify themselves in response to changes in their operating environment. multi agent system (mas) approach is the construction of a complex system as a se...

Behavioral stimulants have widespread potential application in the treatment of affective disorders, disorders of vigilance, and disorders of sleep. Most behavioral stimulants, however, must be used with extreme caution because of undesirable side effects that include stereotypy, anxiolytic effects, and addiction. Adrafinil, developed in France by Louis Lafon Laboratories, is a novel pharmaceut...

Nootropic acitivity of calyces of Hibiscus sabdariffa Linn. was studied in mice. Elevated plus maze and passive avoidance paradigm were employed to evaluate learning and memory parameters. Scopolamine (0.4 mg/kg, i.p.) was used to induce amnesia in mice. The aqueous extracts of calyces of Hibiscus sabdariffa (HS-100 and 200 mg/kg, p.o.) significantly attenuated amnestic deficits induced by scop...