BACKGROUND This study aimed to assess the effect of dehydroepiandrosterone (DHEA) plus climen (estradiol valerate and cyproterone acetate drug combination) on infertility patients with diminished ovarian reserve (DOR) and to determine if the combination of DHEA plus climen is superior to DHEA alone in improving ovarian response. METHODS A total of 124 women were randomized into the DHEA group...

Ovarian tumors associated with hormonal changes of the peripheral iso-sexual precocious puberty are of common presentation. We describe here a rare case of juvenile granulosa cell tumor in a female with central precocious puberty (CPP). An 8-year old girl with CPP presented with vaginal bleeding four months after the diagnosis and before starting treatment with gonadotropin-releasing hormone (G...

BackgroundThe gonadotropin-releasing hormone (GnRH) stimulation test is the gold standard for confirming activation of hypothalamic–pituitary–gonadal axis in central precocious puberty (CPP). However, it time-consuming and costly. Our aim was to search a simpler diagnostic modality CPP by 1) evaluating performance basal serum luteinizing (LH), 2) constructing practical scoring system, 3) determ...

objective: basal fsh levels reflect ovarian response and more formed embryos. we investigated a reliable fsh range to retrieve more oocytes and embryos. materials and methods: two hundred patients in art cycles underwent this study from apr 2007 to sep 2008. patients were divided in three groups based on value of fsh: group a≤8 iu/ml, 8 iu/ml < group b≤10 iu/ml, group c>10 iu/ml and results of ...

Sir, We thank Drs El Hakim and Cahil for their interest and reaction to our paper (de Koning et al. 2008). It is true that the highest measured FSH level is the one that makes clinicians aware of the possible low ovarian reserve. It is known that a normal or moderately elevated FSH can still be found in women with low ovarian reserve due to variable FSH levels and possibly variable cohort size....

The authors investigated immunoactive and bioactive follicle-stimulating hormone (FSH) secretion and clearance in six healthy young men during steady-state infusions of vehicle (basal, B, 28 hours), dihydrotestosterone (DHT, 4.5 days), or estradiol (4.5 days) accompanied by blood sampling at 10-minute intervals for 28 hours. Serum FSH concentrations were assayed by a two-site immunoradiometric ...

Sir, We thank Drs El Hakim and Cahil for their interest and reaction to our paper (de Koning et al. 2008). It is true that the highest measured FSH level is the one that makes clinicians aware of the possible low ovarian reserve. It is known that a normal or moderately elevated FSH can still be found in women with low ovarian reserve due to variable FSH levels and possibly variable cohort size....

OBJECTIVES A significant number of individuals have high serum follicle stimulating hormone (FSH) levels but do not meet the criteria for diagnosis of premature ovarian insufficiency (POI) due to ongoing menstruation. We compared a group of women with elevated FSH levels and POI with a control group in terms of biochemical markers. METHODS In this cross-sectional retrospective study, 38 POI c...

During follicular development, a co-ordinated gonadotrophin and endocrine environment is believed to be essential for normal function of the resulting corpus luteum. Whether differences in the gonadotrophins used to promote follicular development can have lasting effects on granulosa cells after they have undergone luteinization and culture, remains to be studied. We measured steroid production...

OBJECTIVE To evaluate the results of the in vitro fertilization (IVF) cycle outcomes in women whose borderline basal follicle stimulating hormone (FSH) levels were between 10.0 and 11.9 IU/L and to analyze the predictors of pregnancy in this population. MATERIAL AND METHODS A prospective cohort study was performed at an academic teaching hospital; participants were infertile couples in which ...