oxygen therapy might increase damaged tissue oxygenation, turn on the aerobic pathway, and save neurons from death and could improve clinical outcome of the patients with stroke and head trauma. hyperbaric oxygen therapy is accompanied by some unfavorable effects. results of normobaric oxygen therapy on clinical outcomes of patients with stroke were controversial up till now.  this study was th...

Objects: Traumatic brain injury (TBI) is associated with depressed aerobic metabolism and mitochondrial dysfunction. Normobaric hyperoxia (NBH) has been suggested as a treatment for TBI but human studies have produced equivocal results. We used brain tissue oxygen tension (PbrO2) measurement, cerebral microdialysis and near infrared spectroscopy to study the effects of NBH after TBI. We investi...

The emergence of a new hypoxic therapy regimen in which intervals alternate with hyperoxic (30 % O2) led to the need study effectiveness hypoxic-hyperoxic for treatment progressive myopia. An ophthalmologic was performed on 116 male patients from 8 21 years age severe Doppler cerebral vessels, determination indices functional respiratory system were carried out. Interval hypoxia-hyperoxia prove...

Introduction: A large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in Alzheimer's disease (AD). It has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. The aim of this study was to investigate the ...

OBJECTIVES Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. MATERIALS AND METHODS Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day ...

Stroke is a leading cause of death and disability due to disturbance of blood supply to the brain. As brain is highly sensitive to hypoxia, insufficient oxygen supply is a critical event contributing to ischemic brain injury. Normobaric hyperoxia (NBO) that aims to enhance oxygen delivery to hypoxic tissues has long been considered as a logical neuroprotective therapy for ischemic stroke. To da...