BUMC PROCEEDINGS 2002;15:332–335 The Food and Drug Administration (FDA) approved darbepoetin alfa (Aranesp) for treatment of anemia as sociated with chronic renal failure (CRF) in patients on dialysis and patients not on dialysis (1). The manufacturer of the drug also filed an application with the FDA on September 18, 2001, to receive an indication for treatment of anemia in patients with cance...

The prevalence of Chronic Kidney Disease (CKD) in Indonesia 2013-2018 has increased from 0.2% to 0.38%. Patients with CKD have low erythropoietin, so that the production erythrocytes is disrupted and causes anemia. Anemia includes type normocytic-normochromic. Hypochromic occurs because iron reserves cannot be used process erythropoiesis, resulting decreased synthesis hemoglobin. Erythrocytes w...

Chronic Kidney Disease (CKD) will cause anemia which can lead to death. CKD patients undergoing hemodialysis therapy also experience anemia. Therefore, it is necessary check the erythrocyte index consisting of Mean Corpuscular Volume (MCV), Hemoglobin (MCH), and Concentration (MCHC) determine type so that appropriate be given. Objectives: To determined description in at H. Adam Malik General Ho...

Background: Anemia is one of the common complications diabetes mellitus, and their risk in diabetic patients estimated to be 2 – 3 times higher than that without diabetes. Therefore, having a major impact on overall health survival patients. Globally, prevalence concurrent anemia mellitus ranges from 14 45% various ethnic populations worldwide. Objectives: The aim this study was determine among...

This case describes a young man with an unusual cause of severe osteoporosis and markedly deranged bone microarchitecture resulting in multiple fractures. A potentially pathogenic germline variant the runt-related transcription factor 1 (RUNX1) gene was discovered by focused 51-gene myeloid malignancy panel during investigation for his unexplained normochromic normocytic anemia. Further bone-sp...

Normochromic normocytic anemia is common in children with chronic renal failure (CRF) when their glomerular filtration rate is below 35 ml/min/1.73 m2 BSA, but it may develop earlier in some forms of renal disease. An inadequate erythropoiesis due to insufficient erythropoietin synthesis in the kidneys is the main cause of renal anemia. Other reasons include reduced red blood cell lifespan, chr...

b ackground : anaplasma ovis infections can cause clinical symptoms in acute phase and lead to huge economic losses in flocks. the aim of the present study was to investigate the hematological and par- asitological changes in experimental anaplasmosis in sheep with iranian strain of a. ovis . m ethod: five male sheep without any blood parasite infection were selected. one hundred ml hepa-rinize...

Anemia is a frequent finding in patients with myeloma, second only to skeletal lytic lesions. Approximately 70% of patients have anemia at diagnosis a median hemoglobin of approximately 10.5 g/dL. The severity of anemia is important in determining the stage and prognosis of disease as determined by the Durie and Salmon staging criteria. Like anemia of chronic disease, the anemia of myeloma is g...

HE ASSOCIATION of a moderately severe normochromic, normocytic anemia with chronic renal disease is well recognized. Diminished erythropoiesis,’3 hemolysis1’3’4 and hemorrhage5’#{176} have all been shown to contribute to the development of anemia in azotemic patients. However, diminished red cell production appears to be the predominant mechanism in renal anemia. The dynamics of this failure of...