*Present address: Higashi Nippon International University, Iwaki, Fukushima 970, Japan. Present address: Nuclear Physics Institute of the Academy of Science, 250 68 Řez, Čzech Republic. ‡ Present address: RIKEN, Institute for Physical and Chemical Research, Wako, 351-01, Japan. § Present address: Institute for Cosmic Ray Research, University of Tokyo, Tanashi, Tokyo 188, Japan. i Present addres...

Drosophila embryonic neuroblasts generate different cell types at different time points. This is controlled by a temporal cascade of Hb→Kr→Pdm→Cas→Grh, which acts to dictate distinct competence windows sequentially. In addition, Seven up (Svp), a member of the nuclear hormone receptor family, acts early in the temporal cascade, to ensure the transition from Hb to Kr, and has been referred to as...

The tumor suppressor phosphatase and tensin homologue (PTEN) plays distinct growth-regulatory roles in the cytoplasm and nucleus. It has been shown to be preferentially localized to the nucleus in differentiated or resting cells, and to the cytoplasm in advanced tumor cells. Thus, the regulation of PTEN's subcellular localization seems to be critical to its tumor-suppressing functions. In this ...

Telmisartan, a type of angiotensin II (Ang II) receptor inhibitor, is a common agent used to treat hypertension in the clinic. Hypertension increases cardiac afterload and promotes cardiac hypertrophy. However, the ventricular Ang II receptor may be activated in the absence of hypertension. Therefore, telmisartan may reduce cardiac hypertrophy by indirectly ameliorating hypertensive symptoms an...

Nuclear de-excitation codes can be coupled to intranuclear-cascade models to provide coherent and comprehensive descriptions of spallation reactions above ∼150 MeV. This paper discusses the coupling of the Liège Intranuclear Cascade model with two different de-excitation codes: the Statistical Multifragmentation Model and GEMINI++. We present a selection of the results of the simulations that h...

The Tribolium genome contains 21 nuclear receptors, representing all of the six known subfamilies. This first complete set for a coleopteran species reveals a strong conservation of the number and identity of nuclear receptors in holometabolous insects. Two novelties are observed: the atypical NR0 gene knirps is present only in brachyceran flies, while the NR2E6 gene is found only in Tribolium ...

The field of nuclear archaeology aims to develop the methods and tools to verify past production of fissile materials for military purposes, which may become necessary to support the verification of future arms control agreements that envision deeper cuts in the nuclear arsenals. Techniques have been successfully demonstrated for reconstructing historic plutonium production, especially in graph...

The x-ray cascade from antiprotonic atoms was studied for 208Pb and 209Bi. Widths and shifts of the levels due to the strong interaction were determined. Using modern antiproton-nucleus optical potentials, the neutron densities in the nuclear periphery were deduced. Assuming two-parameter Fermi distributions (2pF) describing the proton and neutron densities, the neutron rms radii were deduced f...

D. BARNA for the NA49 Collaboration Central Research Institute for Physics, Konkoly-Thege út 29-33, H-1121, Budapest, Hungary In order to quantify isospin effects in the comparison of elementary to nuclear collisions, p-p and n-p interactions have been studied in the NA49 experiment in addition to p-Pb and PbPb reactions. Together with first measurements of cascade hyperon and Ω production in p...

The standard version (INCL4.2) of the Liège Intra-nuclear Cascade model for spallation reactions has been shown to reproduce reasonably well a large set of experimental data, when coupled to the standard ABLA model. However, some systematic deficiencies were surviving. In order to reduce the latter, an improved model (INCL4.5) has been worked out. The improvements of the model are described her...