We have recently demonstrated that mitochondrial respiratory dysfunction and mitochondrial permeability transition pore opening during postinfarction remodeling are prevented by the Na(+)/H(+) exchange-1 (NHE-1)-specific inhibitor EMD-87580 (EMD). One of the mechanisms underlying the beneficial effect of NHE-1 inhibition on mitochondria could result from the drug's ability to regulate transcrip...

Targeting the inner nuclear membrane roteins destined for the inner nuclear membrane (INM) start out in the peripheral ER. Diffusion from the ER will get them to the contiguous outer nuclear membrane (ONM), but the next step could involve either vesicular transport, short-lived fusions between INM and ONM, or movement along the lipid bilayers surrounding nuclear pores. On page 1051, Ohba et al....

introduction: salivary gland tumors (sgts) are important parts of human neoplasms. the most common sgt is pleomorphic adenoma and the most common malignant sgts are mucoepidermoid carcinoma and adenoid cystic carcinoma (acc). metastasis-associated genes 1 (mta1), a member of the nucleosome remodeling and histone deacetylation complex, is one newly discovered gene which recruits histone deacetyl...

Targeting the inner nuclear membrane roteins destined for the inner nuclear membrane (INM) start out in the peripheral ER. Diffusion from the ER will get them to the contiguous outer nuclear membrane (ONM), but the next step could involve either vesicular transport, short-lived fusions between INM and ONM, or movement along the lipid bilayers surrounding nuclear pores. On page 1051, Ohba et al....

Over the past few decades, actin's presence in the nucleus has been demonstrated. Actin is a key protein necessary for different nuclear processes. Although actin is well known for its functional role in dynamic behavior of the cytoskeleton, emerging studies are now highlighting new roles for actin. At the present time there is no doubt about the presence of actin in the nucleus. A number of st...

RATIONALE Both nuclear factors of activated T cells (NFAT) and nuclear factor-κB (NFκB) are Rel homology domain (RHD)-containing transcription factors whose independent activities are critically involved in regulating cardiac hypertrophy and failure. OBJECTIVE To determine the potential functional interaction between NFAT and NFκB signaling pathways in cardiomyocytes and its role in cardiac h...

Cajal bodies are nuclear sites of small ribonucleoprotein (RNP) remodeling and maturation. A recent study describes the discovery of the Drosophila Cajal body, revealing some interesting insights into the subnuclear organization of RNA processing machineries among different species.

Rationale: Both nuclear factors of activated T cells (NFAT) and nuclear factorB (NF B) are Rel homology domain (RHD)-containing transcription factors whose independent activities are critically involved in regulating cardiac hypertrophy and failure. Objective: To determine the potential functional interaction between NFAT and NF B signaling pathways in cardiomyocytes and its role in cardiac hyp...

Ciliates are well known for their unusual tricks of nuclear remodeling. A roulette-like method for mating type choice in Tetrahymena adds an interesting new twist to their repertoire.

asthma is a chronic inflammatory disease of the airway with extensive airway remodeling. the ethical issues associated with the studies in asthmatic patients, required development of animal model of asthma. animal models of asthma can provide valuable information on several features of asthma pathogenesis and treatment. although these models cannot carry out all clinical features, they are valu...