The incorporation in vivo of compounds labeled with N15 or Cl4 into the purines and pyrimidines of nucleic acid has been repeatedly demonstrated (e.g. (l-3)). W e wish to report observations on the incorporation of radioactive erotic acid in vitro into the pyrimidines of the nucleic acid of rat liver slices. It is believed that this procedure will readily permit the study of precursors of nucle...

Abstract Nucleic acids are one of the most important cellular components. These molecules have been studied both experimentally and theoretically. As all-atom simulations still limited to short time scales, coarse-grain modeling allows study those on a longer scale. Nucleic-Acid united RESidue (NARES-2P) is low-resolution coarse-grained model with two centers interaction per repeating unit. It ...

The nucleic acid content of growing normal and pathological tissues has been a subject of interest in recent years. Several investigators (l-7) have studied nucleic acid changes during embryonic development. It is a well established fact that rapidly growing embryonic tissue has a high concentration of nucleic acid. This was recently extended by Reddy and Cerecedo (S), who observed that gestati...

The more than three decades of research in nucleic acid nanotechnology has led to the thrilling progress rationally designed structures and artificial molecular devices with programmable functions various applications. Nucleic acid–based aggregates feature precise recognition sequence programmability, versatility, as well marked biocompatibility, providing promising candidates for biomedical In...

We report the hybridization properties of a novel artificial nucleic acid: acyclic L-threoninol nucleic acid (L-aTNA). L-aTNA formed a more stable duplex with DNA and RNA than either D-aTNA or serinol nucleic acid (SNA) as the rigidity of the L-form was more optimal for interaction with natural nucleic acids.

Nucleic acids participate in a large number of biological processes. However, current approaches for small molecules targeting protein are incompatible with nucleic acids. On the other hand, the lack of crystallization of nucleic acid is the limiting factor for nucleic acid drug design. Because of the improvements in crystallization in recent years, a great many structures of nucleic acids have...

Nucleic acids are an important class of biological macromolecules that carry out a variety of cellular roles. For many functions, naturally occurring DNA and RNA molecules need to fold into precise three-dimensional structures. Due to their self-assembling characteristics, nucleic acids have also been widely studied in the field of nanotechnology, and a diverse range of intricate three-dimensio...

Extracellular vesicles (EVs), as natural carriers, are regarded a new star in nanomedicine due to their excellent biocompatibility, fascinating physicochemical properties, and unique biological regulatory functions. However, there still some challenges using EVs, including poor targeting ability the clearance from circulation, which may limit further development clinical use. Nucleic acid has f...