coronary artery disease (cad) is the leading cause of mortality in many parts of the world. genome-wide association studies (gwas) have identified several genetic variants associated with cad in low-density lipoprotein receptor (ldlr) locus. this study was evaluated the possible association of genetic markers at ldlr locus with cad irrespective to lipid profile and as well as the association of...

the association of rs10818488 snp located in traf1/c5 region with rheumatoid arthritis (ra), has been picked up by genome-wide association studies. independent studies in different populations revealed inconsistent results. the aim of this study was to investigate the possible association of this snp with ra in iranian population. a total of 362 cases and 422 healthy controls were recruited in ...

introduction: hepatitis b is a potentially life-threatening infection that causes acute infection and chronic hepatitis with progression to cirrhosis and hepatocellular carcinoma (hcc). interleukin-12 (il12) is responsible for activation of th1 immune responses, leading to possible clearance of hbv infection from the host’s body. the host’s immune-genetic background plays an important role in t...

this study has examined the relationship between the xpd lys 751 gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. genomic dna from peripheral whole blood was extracted using standard method to determine the genotype of subjects with rflp-pcr analysis. although this study shows cancer patients harbor more heterozygous genotype (xpd lys 751 gln) (or...

the aim of current study was to investigate the nucleotide sequence of seven trna genes in mitochondrial gene of khorasan’s native chicken and identification of possible mutations in it. for performing it, this part of the gene was cloned using the specific amplification initiators and cloned in the plasmid ptg19-t vector in dh5α strain of e-coli after the sampling and extracting the dna from w...

background: trichomonas vaginalis is the agent of urogenital tract infection that causes human trichomoniasis with some serious health complications. more understanding about genetic features of the parasite can be helpful in the study of the pathogenesis, drug susceptibility and epidemiology of the infection. for this end,we conducted analysis of the actin gene of t. vaginalis by applying the ...

Prochymosin is one of the most important aspartic proteinases used as a milk-clotting enzyme in cheese production. In the present investigation we report sequence of cDNA encoding goat ( Capra hircus ) preprochymosin and compare its nucleotide and deduced amino acid sequences with sequences of other ruminants preprochymosin. As bovine prochymosin, the caprine prochymosin cDNA encodes 365 amino ...

Staphylococcus aureus carrying PVL gene remain major health problem associated with highly virulent infections. Characterization of such gene is important to know the impact and the functional significance of nucleotide variations. PCR and standard sequencing were performed for twelve Sudanese strains from different sources. Protein structures prediction, modeling and physiochemical analysis we...