OBJECTIVES To measure the incidence of cerebral desaturation during high-risk cardiac surgery and to evaluate strategies to reverse cerebral desaturation. DESIGN Prospective observational study followed by a randomized controlled study with 1 intervention group and 1 control group. SETTING Tertiary care center specialized in cardiac surgery. PARTICIPANTS All patients were scheduled for hi...

It has been hypothesized that in chronic obstructive pulmonary disease (COPD), sleep-related hypoxaemia could lead to pulmonary hypertension (PH) and cor pulmonale, even in patients with only mild daytime hypoxaemia. We investigated the relationships between sleep variables and daytime pulmonary haemodynamics in 40 COPD patients with daytime arterial oxygen tension (PaO2) between 60-70 mmHg (8-...

Objective: There are different results on low grade inflammation and metabolic syndrome in patients with obstructive sleep apnea (OSA). We investigated the relation between low grade inflammation and metabolic syndrome in patients with OSA. Methods: This study included 78 OSA patients(AHI ≥5) and 28 control group (AHI <5). Clinical information, body mass index (BMI), Epworth Sleepiness Scale we...

pulmonary hypertension. Eur Respir J 2001; 17: 647–652. 5 Fletcher EC, Donner CF, Midgren B, et al. Survival in COPD patients with a daytime PaO2 greater than 60 mm Hg with and without nocturnal oxyhaemoglobin desaturation. Chest 1992; 101: 649–655. 6 Zielinski J. Effects of intermittent hypoxia on pulmonary haemodynamics: animal models versus studies in humans. Eur Respir J 2005; 25: 173–180. ...

STUDY OBJECTIVES Methods used to express the severity of oxygen desaturation during polysomnography include the average oxygen saturation (AO2), lowest oxygen saturation (LO2), and the percent of the total time with oxygen saturation level lower than 90% (T<90%). We wanted to determine which one of these methods is least variable during different hours of monitoring. DESIGN Prospective, obser...

BACKGROUND In obese patients, reduced functional residual capacity exacerbated by supine position might decrease the effectiveness of pre-oxygenation and the tolerance to apnoea. The aim of this study was to compare the effect of body posture during pre-oxygenation, sitting or supine, on its effectiveness in obese patients. METHODS Forty obese patients (BMI > or =35 kg m(-2)) undergoing surge...

OBJECTIVE Despite advances in anesthetic technique, the incidence of perioperative desaturation in general anesthesia has remained high. Knowledge on factors associated with intraoperative desaturation is relatively scanty. The purpose of the present study was to investigate the distribution of time dependent intraoperative desaturation and factors predicting perioperative desaturation. MATER...

In a paper on obstructive sleep apnoea recently published in the Journal, BOGAARD et al. [1] found correlations between maximal sleep O2 desaturation on the one hand and peak inspiratory flow and forced inspiratory volume % predicted on the other. In their figures 2 and 3, they illustrated this by means of linear regression lines. However, for several reasons the regressions are not linear. One...

We present the cases of three children with patent ductus arteriosus (PDA), pulmonary arterial hypertension (PAH), and desaturation. One of them had desaturation associated with atrial septal defect (ASD). His ASD, PAH, and desaturation improved after successful device closure of the PDA. The other two had desaturation associated with Down syndrome. One had desaturation only at room air oxygen ...

BACKGROUND Oxygen desaturation is not uncommon during bronchoscopy. We sought to identify factors predictive of desaturation during flexible bronchoscopy. METHODS Over eight months, we enrolled 137 randomly selected patients who were undergoing fiberoptic bronchoscopy at our medical center. The patients' oxygen saturation was monitored on their arrival and during the procedure by finger pulse...