Today, approximately 15% of couples have reduced fertility. In most cases the reason is male infertility, usually of genetic origin. Thus, in the context of research in genes involved in reproduction and sex determination, genetic defects in gametogenesis are being extensively studied. The most frequent pathogenic causes of male infertility are Y chromosomal microdeletions and obstructive azoos...

BACKGROUND Male-factor infertility underlies approximately 30% of infertility in couples seeking treatment; of which 10% is due to azoospermia. The development of assisted reproductive technology (ART), enabling the use of epididymal or testicular sperm for fertilization of the partner's oocytes, has made biological fatherhood possible for men with obstructive azoospermia. There is limited know...

Non-obstructive azoospermia used to be considered an untreatable cause of infertility. By the microinjection technique, however, sperm that has been surgically extracted from the testis can be injected into the oocyte cytoplasm. The injected eggs can be transferred to the uterus or fallopian tubes to initiate a pregnancy. A healthy baby boy conceived by using this method was delivered in Novemb...

INTRODUCTION Main categorisation of azospermic is in two grups: nonobstructive azoospermia (NOA) and obstructive azoospermia (OA). We had evaluation of prognostic factors and determinants in sperm retrieval procedures in azoospermic patients. METHODS Retrospective evaluation observed 21 selected patients with NOA and OA azoospermia, after that complete history, physical examination with ultar...

PURPOSE To determine the frequency of genetic alterations in a population of Brazilian infertile men with severe oligozoospermia or non-obstructive azoospermia. MATERIALS AND METHODS Retrospective study of a group of 143 infertile men with severe oligozoospermia or non-obstructive azoospermia from the Andrology Outpatient Clinic of the Human Reproduction Service at the ABC School of Medicine....

From 1 August 1993 until 30 September 1994, 69 couples suffering from azoospermia underwent testicular sperm extraction and intracytoplasmic sperm injection. In 50 couples with obstructive azoospermia a total of 631 metaphase-II oocytes were injected after testicular sperm extraction yielding a 2-PN fertilization rate of 57%. In female patients <40 years of age an ongoing pregnancy rate per tra...

Objective: To investigate the of epididymal width in identifying non obstructive azoospermia (NOA) and obstructive azoospermia (OA). Methods: Using scrotal ultrasound to compare difference of epididymal width between OA (n=18) and NOA (n=10) patients. Results: In the patients with OA average bilateral epididymal width is 0.7+0.1 cm, which is higher than the NOA patients (P<0.05) by ultrasonic m...

The aim of the present study was to verify whether culturing testicular tissue, to obtain a higher percentage of motile spermatozoa and a better post-thaw recovery rate, affected the ratio between single/double-stranded sperm DNA and, consequently, DNA sensitivity to damage. Testicular biopsy samples from men with obstructive and secretory azoospermia, candidates for assisted reproductive treat...