Despite current treatments, including use of angiotensin-converting enzyme (ACE) inhibitors, digoxin, and diuretics, morbidity and mortality remain alarmingly high. An estimated 50% of patients with severe signs and symptoms of heart failure will die within 1 year and 70% within 3 years. Additional pharmacological therapies to mitigate this disorder, such as β-blockers, continue to be investiga...

BANDING of the pulmonary artery has been proposed as a therapeutic procedure for patients with a large left-to-right shunt and pulmonary artery hypertension not amenable to complete correction. It was theorized that by increasing the resistance to outflow from the right ventricle, and thus lowering the pulmonary artery pressure, the size of the left-to-right shunt would diminish, the high outpu...

BANDING of the pulmonary artery has been proposed as a therapeutic procedure for patients with a large left-to-right shunt and pulmonary artery hypertension not amenable to complete correction. It was theorized that by increasing the resistance to outflow from the right ventricle, and thus lowering the pulmonary artery pressure, the size of the left-to-right shunt would diminish, the high outpu...

In this study, a lumped compartment cardiovascular model is developed to predict pulsatile pressures in the systemic and pulmonary circulation as well as in finger arteries. Essential compartments of the model include arterial and venous pulmonary, left and right ventricles, and arterial and venous systemic compartments. A pulsatile left ventricle is incorporated to be the source of pulse waves...

This article investigates the relationships between heart valve closure timing intervals and left ventricular systolic blood pressure (LVSBP). For this investigation, the cardiopulmonary system is modeled as an analog circuit, including heart chambers, the distal and proximal aorta, distal and proximal systemic arteries/veins, systemic capillaries, the vena cava, the distal and proximal pulmona...

BACKGROUND Metabolic disease can lead to intrinsic pulmonary hypertension in experimental models. The contributions of metabolic syndrome (MetS) and obesity to pulmonary hypertension and right ventricular dysfunction in humans remain unclear. We investigated the association of MetS and obesity with right ventricular structure and function in patients without cardiovascular disease. METHODS AN...

A 55-year-old male was admitted for evaluation of severe dyspnoea and hypoxaemia. Physical examination upon admission showed elevated jugular venous pressure and an accentuated second heart sound. Chest radiograph showed cardiomegaly with increased bibasilar markings. Arterial blood gas analysis while breathing room air showed marked hypoxaemia. High resolution computed tomography angiography o...

Oxidative phosphorylation was measured polarographically in mitochondria isolated from normal ventricles and from the ventricles of guinea pigs and cats with experimental heart failure produced by constriction of the aorta or pulmonary artery. The presence of heart failure was proved by the study of myocardial mechanics in vitro, by cardiac catheterization, and by post-mortem examination. Mitoc...

Chronic obstructive pulmonary disease (COPD) is an due to inflammatory processes of the respiratory tract and lung parenchyma. In some cases COPD, changes in vessels are found which not uncommon, causing impaired gas exchange hypertension associated with increased morbidity mortality. Pulmonary increase mean artery pressure (Pulmonary Arterial Pressure) greater than or equal 25 mmHg at rest as ...