PURPOSE. In Pseudomonas aeruginosa ocular infection, T-helper cell 1–responsive mouse strains are susceptible (the cornea perforates), and neutralization of IFNbefore infection has been shown to delay the onset of perforation. IFNis the predominant cytokine induced by IL-12, and positive regulation of IL-12 by IFN, if unchecked, leads to excessive cytokine production and toxicity. Despite its p...

IMPORTANCE The reported outcomes of ocular mycobacterial infection are commonly unfavorable. This study is among the first to elucidate factors associated with poor outcomes, as well as highlight the continued controversies in therapy, particularly the role of oral corticosteroids. OBJECTIVE To describe presentations and outcomes of mycobacterial ocular disease in the Midwestern United States...

PURPOSE An important phase in the development of an ocular herpes simplex virus type 1 (HSV-1) subunit vaccine is the identification of an efficient, safe, and adjuvant-free antigen delivery system capable of inducing and sustaining long-term memory T-cell protective immunity. This study was conducted to test the hypothesis that immunization with self-adjuvanting lipopeptide bearing HSV-1 glyco...

BACKGROUND Methicillin-resistant Staphylococcus aureus (MRSA) infection is an important public health issue. The study aimed to determine the prevalence of ocular infections caused by MRSA and to identify the clinical characteristics and antibiotic susceptibility of ocular MRSA infections by comparing those of ocular methicillin-sensitive S. aureus (MSSA) infections. METHODOLOGY/PRINCIPAL FIN...

background and aims: epstein-barr (ebv) virus infection is very common in the population. virus belongs to the family herpesviridae, whose representatives are characterized by the ability to cause the human body latent persistent infections. the goal of study is to assess ebv infection frequency and pcr method in the choice of ebv in inflammatory eye disease, comparing with ebv presence in eye ...

The risk of blindness caused by ocular toxoplasmosis supports efforts to improve our understanding for control of this disease. In this study, the involvement of CD8(+), CD4(+), B cell, and IL-10 gene in the immune response of primary ocular infection with the temperature-sensitive mutant (ts-4) of the RH Toxoplasma gondii strain, and in the protective immunity of ocular ts-4 vaccination and ch...

BACKGROUND The purpose of this study was to evaluate the immunoglobulin (Ig) G avidity of serological toxoplasmosis testing in patients with ocular inflammation and to determine the clinical manifestations of ocular toxoplasmosis. METHODS A retrospective review of all patients presenting with ocular inflammation to the Hospital Universiti Sains Malaysia, Kelantan, Malaysia between 2005 and 20...

Usanee Reinprayoon*, Nitipong Permpalung*, Ngamjit Kasetsuwan, Rongpong Plongla, 2 Leonel Mendoza, Ariya Chindamporn 3 Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, Bangkok, 4 Thailand, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand, 5 Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, 6 Thailand, De...

Ocular lesions are a common manifestation of toxoplasmosis in cats. In this survey, 10 healthy Syrianmice were infected through intraperitoneal inoculation of bradyzoites of Toxoplasma gondii (Tehran strain).Mice were killed 30 days after inoculation and the suspension of their brains was prepared, after confirmationof the infection. Seven kittens were fed with the infected mice brain suspensio...

BACKGROUND Varicella is a common infectious disease primarily of childhood that is usually benign and self-limited. It is, however, increasingly seen in adults who are at a higher risk of severe infection. Ocular complications of varicella are relatively uncommon and have been rarely described in adults. We describe herein five adults who developed ocular involvement in association with primary...