Introduction: To investigate the nonlinear kinetics of in vitro hepatic uptake the OATP substrate, Pitivastatin, was used as a probe. Experiments were conducted using freshly isolated rat hepatocytes, utilising the ‘oil spin’ methodology described by Hassen et al [1]. Briefly, freshly isolated rat hepatocytes were incubated with Pitvastatin (5–300μM). At 10 s, 30 s, 50 s and 70 s aliquots were ...

monolithic aerogels of high molecular weight polyethylene (mw= 3x106- 6x106 g/mol) have been prepared by solvent extraction with supercritical carbon dioxide from thermoreversible gels prepared in decalin. these low density and highly porous aerogels present an apparent porosity up to 90%. the aerogel morphology observed by scanning electron microscopy (sem) is characterized by spherulitic stru...

The objective of this study was to evaluate how the vehicles of choice affect the pharmacokinetics of orally administered Fluoranthene [FLA] in rats. Fluoranthene is a member of the family of Polycyclic Aromatic Hydrocarbon chemicals. Fluoranthene exposure to humans may occur as a result of cigarette smoking, consumption of contaminated food and water, heating woods in stoves and boilers, indus...

Studies evaluating the effects of high-saturated fat diets on cardiac function are most often confounded by diet-induced obesity and by systemic insulin resistance. We evaluated whether coconut oil, containing C12:0 and C14:0 as main fatty acids, aggravates pressure overload-induced cardiomyopathy induced by transverse aortic constriction (TAC) in C57BL/6 mice. Mortality rate after TAC was high...

Pseudomonas aeruginosa is a ubiquitous fluorescent, rod-shaped pseudomonad, with high metabolic capacity, and potential for application in processes to remove recalcitrant compounds such as petroleum hydrocarbons (PHC) from the environment. The bacterium persists sites highly selective pressures those contaminated by PHC. One of bacterium's strategies colonize biofilms which enhance its protect...

Monolithic aerogels of high molecular weight polyethylene (Mw= 3x106- 6x106 g/mol) have been prepared by solvent extraction with supercritical carbon dioxide from thermoreversible gels prepared in decalin. These low density and highly porous aerogels present an apparent porosity up to 90%. The aerogel morphology observed by scanning electron microscopy (SEM) is characterized by spherulitic stru...

OBJECTIVES The aim of this study was to investigate the mechanism of action of tea tree oil and its components against Candida albicans, Candida glabrata and Saccharomyces cerevisiae. METHODS Yeast cells were treated with tea tree oil or components, at one or more concentrations, for up to 6 h. During this time, alterations in permeability were assessed by measuring the leakage of 260 nm abso...

oil uptake occurs mainly during cooling immediately after frying. post-frying centrifuge step used to remove the attached oil to the surface of friedproduct. response surface methodology (rsm) technique was used to develop models for the responses to the centrifugal force (100, 200 and 300 rpm) and centrifugal time (20, 50 and 80 s), frying temperature (140, 170 and 200 c) and frying time (4, ...

During atherogenesis, a pathological accumulation of lipids occurs within aortic intimal macrophages through uptake of oxidised low-density lipoprotein (LDL) via scavenger receptors. Here we investigate whether some of the anti-atherosclerotic effects ascribed to dietary fish oil are mediated through effects on macrophage intercellular adhesion molecule 1 (ICAM-1) and scavenger receptor express...

AIMS Evaluation of the cellular effects of Origanum compactum essential oil on Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 29213. METHODS AND RESULTS The damage induced by O. compactum essential oil on these two strains has been studied using different techniques: plate count, potassium leakage, flow cytometry (FC) and transmission electron microscopy (TEM). The results s...