In this study it is investigated how the modulation of surface windstress by tropical instability waves (TIWs) feeds back onto TIWs and plays a role in their fundamental properties. An ocean general circulation model is used, that reproduces qualitatively well the properties of TIWs when forced by climatological winds. The ocean model is coupled to the atmosphere through a simple parameterizati...

BACKGROUND Rush oral immunotherapy (OIT) combined with omalizumab (OMB) has been reported to be an effective and safe treatment for severe milk allergies. However, no report has described long-term follow-up observations after OMB discontinuation. The purpose of this case report was to evaluate the safety and efficacy of rush OIT in combination with OMB during a long period of treatment. CASE...

OBJECTIVE To evaluate the relationship between findings via osteomeatal unit computed tomography (OMU CT) of the olfactory cleft and olfactory function in patients with chronic rhinosinusitis (CRS). DESIGN Retrospective review of medical records. SETTING Referral center. PARTICIPANTS Two hundred ten patients with CRS who underwent OMU CT and olfactory function tests were included in this ...

Background Milk allergy is the most common food allergy in infants and young children. Typical milk allergy symptoms involve hives, vomiting, or even anaphylaxis. For cow’s milk, strict avoidance is difficult because milk proteins are very ubiquitous. Oral immunotherapy (OIT) is an effective therapeutic option to induce milk oral tolerance. However, the immune mechanisms underlying this treatme...

BACKGROUND Small studies suggest peanut oral immunotherapy (OIT) might be effective in the treatment of peanut allergy. We aimed to establish the efficacy of OIT for the desensitisation of children with allergy to peanuts. METHODS We did a randomised controlled crossover trial to compare the efficacy of active OIT (using characterised peanut flour; protein doses of 2-800 mg/day) with control ...

Specific oral immunotherapy (OIT) is a proven therapeutic option in children with persistent food allergy. Several cases of eosinophilic esophagitis have been reported during the long term follow-up, but not inflammatory bowel diseases. The role of food allergy in the pathogenesis of these diseases is unknown. We present an 11 year-old girl who developed cow’s milk allergy (CMA) at the age of 5...

The progressive increase in incidence in cow’s milk proteins allergy (CMPA) in the past decades required primary prevention strategies for children at high-risk. Evidence of the role of gut microbiota in promoting the maturation of the immune system during early life encouraged supplementing the diet with probiotics in order to facilitate tolerance and delay or prevent sensitization. The effica...

Background Egg allergy is one of the most common food allergies of childhood with an estimated prevalence of 2.6 %. Allergic reactions to egg may vary from atopic dermatitis to systemic anaphylaxis. Although traditionally the only treatment is dietary avoidance, oral immunotherapy (OIT) appears as a promising approach to induce eggtolerance. However, the immune mechanisms underlying this treatm...

BACKGROUND IgE-mediated wheat allergy affects around 0.5% of the population, and current management is based on avoidance. We propose an active intervention to promote tolerance in wheat-allergic children. OBJECTIVES To investigate the efficacy and safety of an oral immunotherapy (OIT) protocol with wheat to treat IgE-mediated wheat-allergic children. METHODS Six wheat allergic patients ass...

cow’s milk allergy (cma) is the most frequent food allergy in children and oral immunotherapy (oit) is a promising approach for treatment of patients. the most challenging cases are anaphylactic with coexisting asthma and proposing safe protocols is crucial especially in high risk groups. considering that cma varies among patients, an individualized oit protocol would be beneficial to achieve a...