For many decades, researchers have investigated the relationships between health status and consumption of extra virgin olive oil. Extra virgin olive oil (and oleic acid) is considered important for the prevention of coronary heart disease. While the biomolecular aspects involving G protein need further research, oleic acid levels in platelets may be a discriminating factor, together with linol...

We recently described a primarily reduced palmitate oxidation in myotubes established from type 2 diabetic subjects, whereas triacylglycerol (TAG) accumulation seemed to be adaptive. However, it is still uncertain whether these changes are similar for saturated and unsaturated fatty acids and whether high concentrations of glucose and/or insulin may change this picture. Studies of palmitic acid...

In order to determine exactly the effect on the nervous system of concentration of dietary oleic acid on the fatty acid composition of different part of the nervous system, triglycerides were synthesized using chemical and enzymological methods. The dose-effect was determined using an experimental protocol with seven groups of rats who received a diet in which the oleic acid level varied from 0...

Orosensory perception of dietary fat varies in individuals, thus influencing nutritional status. Several studies associated fat detection and preference with CD36 or 6-n-propylthiouracil (PROP) sensitivity. Other studies have not confirmed the latter association. We analyzed the relationship between orosensory perception of oleic acid, two CD36 variants, and PROP tasting. Thresholds of oleic ac...

BACKGROUND 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors have several pleiotropic effects, including anti-inflammatory properties, and are reported to improve endothelial functions. Pathophysiologically, acute lung injury (ALI) is caused by a severe inflammatory response and endothelial dysfunction. OBJECTIVE To investigate the effects of simvastatin (an HMG-CoA reduct...

RATIONALE Most models of acute lung injury in mice have yet to be fully characterized. OBJECTIVES To directly compare and contrast endotoxin and oleic acid models of acute lung injury in mice in terms of their physiologic, biochemical, histopathologic, and imaging manifestations. METHODS Survival studies, lung weights, x-ray computed tomographic scanning, light and electron microscopy, bron...

zinc oxide nano-particles with the average diameter of about 25 nm were modified with different mole ratios of trimetoxyvinyl silane (tmvs) and oleic acid, as coupling agents, in order to modify their surface properties and render them more hydrophobic. then, dispersibility of the surface modified nano-particles was examined in some monomers with different levels of hydrophobicity, including me...

A gustatory transduction mechanism for free fatty acids (FFAs) has been described in isolated rat taste receptor cells; however, the ability of behaving rats to detect FFAs has not been characterized. Through conditioned taste aversion (CTA) methodology, this study defines the ability of rats to detect and avoid the two principal FFA components of corn oil, linoleic and oleic acid. Following ta...