BACKGROUND Allogeneic hematopoietic cell transplantation (allo-HCT) has been proposed as treatment for multiple sclerosis (MS) and other autoimmune diseases. AIMS To describe the effects of allo-HCT on the course of MS in a 49-year-old woman with longstanding progressive MS who was treated with allo-HCT for follicular lymphoma. METHODS Non-myeloablative conditioning allo-HCT, examination fo...

The presence of oligoclonal bands (OCBs) of immunoglobulin G (IgG) in CSF provides evidence for the occurrence of a humoral immune response, but it is not always appreciated that the oligoclonal IgG may have originated in the serum. To determine the diagnostic significance of serum OCBs 146 patients with serum OCBs were identified among 1874 patients with suspected neurological disorders (7.6%)...

A When we consider that creatinine and uric acid, for example, are excreted in concentrations of about 15 and 5 mmoLfL, we can already observe positive biases caused by these interferencesat a sample:reagent volume ratio of 1:5 (1). However, this ratio does not yet permit measurement of microalbuminuria. Thus, the interferingreactions of urinary components with bromphenol blue preclude use of t...

IgG oligoclonal bands (OCB) are detected in the cerebrospinal fluid (CSF) of more than 90% of multiple sclerosis (MS) patients and are considered the immunological hallmark that supports MS diagnosis. OCB are not unique to MS but are also observed in chronic CNS infections, where they target their causative agents (1–3). However, the target specificities of the IgG within OCB in MS have remaine...