We have previously isolated epidermal growth factor (EGF)-responsive multipotent progenitor cells from the early postnatal rodent cerebral cortex independent of generative zones. In this study we have examined the mechanisms regulating the generation of differentiated oligodendrocytes (OLs) from these multipotent cells. Although cultures of primary cortical OL progenitor cells propagated at clo...

To define the spatiotemporal development of and simultaneously select for oligodendrocytes (OLs) and Schwann cells (SCs), transgenic mice were generated that expressed a bacterial beta-galactosidase (beta-gal) and neomycin phosphotransferase fusion protein (betageo) under the control of murine 2'3'-cyclic nucleotide 3'-phosphodiesterase (muCNP) promoters I and II. Transgenic beta-gal activity w...

The Defense Meteorological Satellite Program-Operational Linescan System (DMSP-OLS) stable lights products are made using operational OLS data collected at high gain settings, resulting in sensor saturation on brightly lit areas, such as city centers. This has been a paramount shortcoming of the DMSP-OLS stable lights time series. This study outlines a methodology that greatly expands the dynam...

Spatial relationship between vegetation and rainfall in Central Kazakhstan has been modelled using Normalized Difference Vegetation Index (NDVI) and rainfall data from weather stations. The modelling based on application of two statistical approaches: conventional ordinary least squares (OLS) regression, and geographically weighted regression (GWR). The results support the assumption that the a...

This study examined the factors that influence agricultural production and exports with specific reference to the natural rubber in India. Secondary data was used for this study. Ordinary Least Squares (OLS) technique was used in analyzing the relevant data. The OLS findings revealed that natural rubber production is significantly (p<0.05) by export of natural rubber (β=0.05), stock (β=0.21) an...

This paper proposes a semiparametrically modified OLS (SM-OLS) estimator and a semiparametrically modified IV (SM-IV) estimator via kernel method for linear cointegrating models when cointegrating equilibrium errors respond instantaneously to changes of the first-differenced integrated regressor in the linear cointegrating models. Both the proposed estimators are shown to have a mixed normal li...

Anthocyanidin reductase (ANR) is a key enzyme in the ANR biosynthetic pathway of flavan-3-ols and proanthocyanidins (PAs) in plants. Herein, we report characterization of the ANR pathway of flavan-3-ols in Shuchazao tea (Camellia sinesis), which is an elite and widely grown cultivar in China and is rich in flavan-3-ols providing with high nutritional value to human health. In our study, metabol...

Flavan-3-ols consist of flavan-3-ol monomers and polymers with different degrees of polymerization (DP). In this study, flavan-3-ol extracts from grape seeds were well separated into three fractions including monomers, oligomers (2 < DP < 10) and polymers (DP > 10), by means of normal-phase HPLC-MS. The different patterns of these three fractions were analyzed in three Vitis vinifera cultivars ...

Fibroblast growth factors (FGFs) have been implicated in numerous cellular processes, including proliferation, migration, differentiation, and survival. Whereas FGF-2, the prototypic ligand in a family of 22 members, activates all four tyrosine kinase FGF receptors (FGFR1-FGFR4), other members demonstrate a higher degree of selectivity. Oligodendrocytes (OLs), the myelin-producing cells of the ...