background: lactating adenoma is a benign breast mass related to physiological changes during pregnancy and increased estrogen level. fibroadenoma and breast cancer should be considered in the differential diagnosis of this lesion. the purpose of this study was to report cases of lactating adenoma in breast cancer research center (bcrc) and review the relevant literature. methods: all patients ...

Association studies in large series of breast cancer patients can be used to identify single-nucleotide polymorphisms (SNP) contributing to breast cancer susceptibility. Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk. Data from molecular studies suggest a functional interaction between these genes. We therefore investigated the eff...

objective: to assess the level of awareness on breast cancer among women of reproductive age. materials and methods: a cross-sectional descriptive study was conducted in opd of dhaka medical college hospital among the 175 respondents by face to face interview using pretested semi structured questionnaire. results: one forth (23%) aged 21-25 years, mostly muslim (86.3%), housewives (72.57%), had...

Much research on early-onset breast cancer families has been performed and has shown that breast cancer in many of these families is linked to either BRCA1 or BRCA2. Fewer studies have examined the role of genetic predisposition in postmenopausal breast cancer. A nested case-control family study of breast cancer was conducted within the Iowa Women’s Health Study, a population-based prospective ...

Relatives of postmenopausal breast cancer patients have a greater risk of breast cancer than do women with no family history of the disease. However, no study has previously examined the contribution of other breast cancer risk factors to risk in these relatives, thus precluding the ability to discern between shared environment or genes as the cause of familial aggregation. We conducted a neste...

Based on epidemiological data we can assume that at least some malignant melanoma (MM) and breast cancer cases can be caused by the same genetic factors. CDKN2A, which encodes the p16 protein, a cyclin-dependent kinase inhibitor suppressing cell proliferation, is regarded as a major melanoma susceptibility gene and the literature has also implicated this gene in predisposition to breast cancer....

The relationship between thyroid and breast diseases has been documented, but the clinical significance of Graves' disease and breast cancer is unclear. We present a young patient with a history of Graves' disease who developed a multicentric infiltrating ductal carcinoma of the breast several months after discontinuing her treatment with propylthiouracil. Early-onset breast cancer in women wit...

Variation in the detection, signaling, and repair of DNA damage contributes to human cancer risk. To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another malignancy (breast-other, n=42), early-onset breast cancer (early-onset, age <or=35; n=38), thyroid cancer (n=68), long-lived cancer-free individuals (hyper-norm...

background: breast cancer is third order malignancy in women among other malignancies.   various studies showed that incidence of breast cancer can be lower down by early detection of breast cancer. mammographic screening is considered more effective modality in detecting early stage breast cancer in women who are at elevated risk for breast cancer. the aim of this study is to report the result...

PURPOSE The lower breast cancer incidence in Asian populations compared with Western populations has been speculated to be caused by environmental and genetic variation. Early-onset breast cancer occupies a considerable proportion of breast cancers in Asian populations, but the reason for this is unclear. We aimed to examine miRNA expression profiles in different age-onset groups and pathologic...