K.K. Oguz A. Kurne A.O. Aksu E. Karabulut A. Serdaroglu S. Teber S. Haspolat N. Senbil S. Kurul B. Anlar BACKGROUND AND PURPOSE: Myelin instability and citrullinated myelin basic protein have been demonstrated in the brains of patients with chronic and fulminating forms of multiple sclerosis (MS). Our aim was to trace citrulline in the brains of patients with early-onset MS by using proton MR s...

Case Report A 36-year-old woman with psoriatic arthritis who had received etanercept for 4 months (25 mg s.c. twice weekly) presented with a 1-week history of right eye pain and vision decline. Three weeks previously, she had developed the same symptoms in the left eye that resolved spontaneously. There was no family history of neurological disorders. Two years previously, she received (partial...

The association of pregnancy and onset or relapse of multiple sclerosis is well known to every clinician and raises practical problems in clinical work. The problem of the relationship between multiple sclerosis and pregnancy and childbirth had been the subject of several investigations. Early investigators (Beck, 1913) considered pregnancy so detrimental to patients with multiple sclerosis tha...

INTRODUCTION Paediatric multiple sclerosis (MS) carries a relatively higher mortality and morbidity than adult MS. Paediatric MS symptoms and paraclinical findings at the first demyelinating event have never before been characterised in a Danish setting. The aim of this study was to compare symptoms and paraclinical findings at the first demyelinating event in paediatric MS with those of an adu...

The Danish Multiple Sclerosis Registry contains information about all Danish patients in whom multiple sclerosis has been diagnosed since 1948. The purpose of this study was to analyse trends in survival and causes of death of these patients and to compare them with those of the general population. The study comprised all patients with onset in the period 1949-1996. All case records were valida...

Prognosis of multiple sclerosis is highly variable. Clinical variables have been identified that are assessable early in the disease and are predictors of the time from the disease onset to the onset of irreversible disability. Our objective was to determine if these clinical variables still have an effect after the first stages of disability have been reached. We determined the dates of diseas...

OBJECTIVES To determine the underlying causes of death in a large population based register series of patients with multiple sclerosis. METHODS The Danish Multiple Sclerosis Registry, which contains virtually all diagnosed cases of multiple sclerosis in Denmark who were alive in 1949 plus cases with onset of multiple sclerosis in the period 1949-93, who have been diagnosed and notified by 1 J...

BACKGROUND Epidemiologic similarities between Hodgkin lymphoma in young adults (i.e., between 15 and 44 years old) and multiple sclerosis have led to the suggestion that these diseases may have related etiologies. Previous investigations have not supported this hypothesis, but the negative results could have been caused by methodologic problems. We therefore assessed the risk of developing Hodg...