BACKGROUND Women with inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes are recommended to undergo a number of intensive cancer risk-reducing strategies, including prophylactic mastectomy, prophylactic oophorectomy, and screening. We estimate the impact of different risk-reducing options at various ages on life expectancy. METHODS We apply our previously developed Monte Carlo simulati...

BACKGROUND For BRCA1 or BRCA2 mutation carriers, decision analysis indicates that prophylactic surgery or chemoprevention leads to better survival than surveillance alone. OBJECTIVE To evaluate the cost-effectiveness of the preventive strategies that are available to unaffected women carrying a single BRCA1 or BRCA2 mutation with high cancer penetrance. DESIGN Markov modeling with Monte Car...

B ilateral prophylactic oophorectomy (also known as ovariectomy) is undertaken commonly and routinely as a prophylactic measure in women who are not at a known increased risk of ovarian cancer. In the UK in 2003, for example, about 41 000 women had an elective hysterectomy for benign conditions. Of these about 19 000 women aged less than 60 years, simultaneously had bilateral oophorectomy. Hyst...

OPINION STATEMENT In women at increased risk of developing ovarian cancer, risk-reducing salpingo-oophorectomy is the only intervention that has been shown to decrease mortality from ovarian cancer and is the standard of care for risk reduction. Prophylactic salpingectomy with delayed oophorectomy should be considered in high-risk premenopausal women in the setting of a clinical trial.

Background: Bilateral salpingo-oophorectomy in women may lead to metabolic consequences in patients. This study was performed to determine the glucose tolerance and lipid profile after menopause resulting from bilateral salpingo-oophorectomy. Methods: From September 2011 to March 2013, 31 women participants aged 46-52 years who underwent hysterectomy and bilateral salpingo-oophorectomy for ben...