the ip3r calcium release channel has been simulated using a stochastic simulation algorithm (ssa;gillespie algorithm) and de young-keiser model. a set of different concentration for cat' and ip3 havebeen used. considering the number of molecules in each state, a non linear behavior of the system can beseen clearly. the inhibiting role of the ca+2 on the open state (x110) has been studied. the d...

The simplest water diversion method in irrigation systems is using intakes. Measuring the mean velocity is one of the essential hydraulic parameters in increasing the efficiency of the intake. In this study, the mean velocity was predicted for different width ratios of an intake using ANN-MLP neural network model. In order to do that, the flow field within a 90-degree intake was first simulated...

Estimates of denitrification based on standard methods often cannot easily be extrapolated to entire ecosystems because of high spatial heterogeneity in rates of denitrification. Diel changes in the concentration of dinitrogen (N2) in running waters provide the basis for estimating denitrification by an open-channel technique in much the same way that ecosystem metabolism can be estimated from ...

Open channel block is a process in which ions bound to the inside of a channel pore block the flow of ions through that channel. Repulsion of the blocking ions by depolarization is a known mechanism of open channel block removal. For the NMDA channel, this mechanism is necessary for channel activation and is involved in neuronal plasticity. Several types of transient receptor potential (TRP) ch...

Recent studies of the bacterial mechanosensitive channel MscL have combined a number of different approaches to come up with a model for the channel gating mechanism.

ntercalation—the slotting of cells in between one another—is an established method for converting short and fat into long and slim. This is all very well in slippery, adhesion-sparse mesenchymal tissues. But many such extension events occur in epithelial tissues, where cells are glued together by adhesion complexes. Claire Bertet, Lawrence Sulak, and Thomas Lecuit (IBDM, Marseille, France) now ...

this paper presents the results of a numerical study on the removal process of fluid particles under the influence of mixed convection in a horizontal channel with an open cavity. the bottom wall of the cavity is heated at a constant temperature (th), while the top wall is maintained at a relatively low temperature (tc). fluid with a uniform velocity (uo) and temperature (tc) is introduced into...

The type 1 ryanodine receptor (RyR1) mediates Ca2+ release from the sarcoplasmic reticulum to initiate skeletal muscle contraction and is associated with muscle diseases, malignant hyperthermia, and central core disease. To better understand RyR1 channel function, we investigated the molecular mechanisms of channel gating and ion permeation. An adequate model of channel gating requires accurate...