Biophysical property and water evaporation retardation through a lipid nanofilm can be altered by model tear protein topical ophthalmic formulation. Evaporation rate dynamic surface pressure were measured using sessile drop technique. Water evaporations from 5 individual solutions, their mixture, 6 formulations quantified. nanofilms spread on electrolyte assessed. Model solution reduced evapora...

BACKGROUND The purpose of this study was to evaluate the safety and tolerability of besifloxacin ophthalmic suspension 0.6% compared with moxifloxacin ophthalmic solution 0.5%, when used for infection prophylaxis following uncomplicated phacoemulsification clear cornea surgery using sutureless corneal incision. METHODS This prospective, two-site, parallel-group, investigator-masked clinical s...

PURPOSE In order to determine whether the one-component method for calculating drug concentration in the aqueous (AQC(max)) is useful for selecting an appropriate ophthalmic solution, six general purpose antimicrobial ophthalmic solutions already on the market were investigated. METHODS The drugs examined were levofloxacin (LVFX), chloramphenicol (CP), erythromycin lactobionate (EM), micronom...

PURPOSE To compare the clinical efficacy and safety of lodoxamide 0.1% ophthalmic solution with levocabastine 0.05% ophthalmic suspension, each given four times daily (QID) for three months to patients with vernal keratoconjunctivitis (VKC). METHODS The study was conducted multinationally according to a triple-masked parallel design in 95 VKC patients, with assessments at baseline then monthl...

BACKGROUND To evaluate the safety of besifloxacin ophthalmic suspension 0.6% when used in laser-assisted in situ keratomileusis (LASIK) prophylactic antibiotic regimens. METHODS Retrospective surveillance of LASIK surgery cases where besifloxacin ophthalmic suspension 0.6% or moxifloxacin ophthalmic solution 0.5% were prescribed as prophylactic medications. Surgeons from nine US surgical cent...

PURPOSE The aim of the study was to evaluate the safety of besifloxacin ophthalmic suspension 0.6% as antibacterial prophylaxis in the surgical setting. METHODS Two prospective safety surveillance studies were conducted-one in the cataract surgery setting and the other in the laser-assisted in situ keratomileusis (LASIK) surgery setting. Cases from patients aged 18 years and above were eligib...

The objective o f this study was to develop simple and rapid method for the determination of ciprofloxacin hydrochloride in ophthalmic solution using UV spectrophotometry. The intrinsic absorbance of ciprofloxacin was measured directly at 275 nm. The calib ration graph was linear over the range 2.0–7.0 μg mL with relative standard deviations (RSD) values ranging from 1.55 to 2.47% (n=6). The me...

BACKGROUND The purpose of this study was to characterize intraocular pressure (IOP) reduction throughout the day with travoprost ophthalmic solution 0.004% dosed once daily in the evening. METHODS The results of seven published, randomized clinical trials including at least one arm in which travoprost 0.004% was dosed once daily in the evening were integrated. Means (and standard deviations) ...

BACKGROUND Bimatoprost ophthalmic solution 0.03% was approved in the US for reducing intraoccular pressure (IOP) based on two double-masked, active-controlled clinical trials. Four additional long-term studies (≥12 months) were conducted; however, the aggregate safety profile of the six studies has not been reported. METHODS Adverse events (AEs) were pooled from six double-masked, active-cont...

BACKGROUND Posterior blepharitis is an eyelid disease primarily of the meibomian glands. Bacteria and chronic inflammation are contributing factors for meibomian gland disease, which leads to ocular surface and tear film alterations and chronic patient symptoms. Azithromycin 1.0% ophthalmic solution is a broad spectrum topical antibiotic with anti-inflammatory properties. The present study eval...