PURPOSE To report a case of Wolfram syndrome (WS) characterized by diabetes mellitus, diabetes insipidus, progressive optic atrophy, and deafness. CASE REPORT A 19-year-old female patient, a known case of diabetes mellitus type I from six years before, presented with progressive vision loss since four years earlier. On fundoscopic examination, she had bilateral optic atrophy without diabetic ...

LEBER'S disease, with its sudden onset in adolescence or early adult life, its rapid course, and puzzling mode of inheritance, has overshadowed other forms of inherited optic atrophy. The early literature contained many cases of "atypical" Leber's disease, but the continued emphasis on the established form, even in the monumental review by Bell (1931), hampered the emergence of other forms as s...

purpose: to report a case of anterior ischemic optic neuropathy (aion) after ingestion of tadalafil (a drug for management of erectile dysfunction). patient and findings: a healthy 26-year-old male was referred due to loss of vision and visual field defect in his left eye a few days after using tadalafil. visual loss was progressive during the following days. examination revealed disc swelling ...