Several stages in the lens determination process have been defined, though it is not known which gene products control these events. At mid-gastrula stages in Xenopus, ectoderm is transiently competent to respond to lens-inducing signals. Between late gastrula and neural tube stages, the presumptive lens ectoderm acquires a lens-forming bias, becomes specified to form lens and begins differenti...

We demonstrate two high-speed electro-optic devices: an integrated lens/scanner and a variable radius collimating lens stack fabricated on a single crystal of Z-cut LiTaO3. The lens and scanner components consist of lithographically defmed domain-inverted regions extending through the thickness of the crystal. A lens power of 0.233 cm'kV', a deflection angle of 12.68 mrad kV', and a scan rate o...

Optic cup morphogenesis (OCM) generates the basic structure of the vertebrate eye. Although it is commonly depicted as a series of epithelial sheet folding events, this does not represent an empirically supported model. Here, we combine four-dimensional imaging with custom cell tracking software and photoactivatable fluorophore labeling to determine the cellular dynamics underlying OCM in zebra...

Posterior capsulorhexis with optic capture was originally described by Gimbel and DeBroff [4] to maintain a clear visual axis after pediatric cataract surgery. This technique involves capturing the IOL optic through a primary posterior continuous curvilinear capsulorhexis (PCCC), while the haptics remain within the capsular bag (Figure 1). Studies have demonstrated this to be a valuable techniq...

Heterozygous mutations in PAX6 are causative for aniridia, a condition that is frequently associated with juvenile glaucoma. Defects in morphogenesis of the iridocorneal angle, such as lack of trabecular meshwork differentiation, absence of Schlemm's canal and blockage of the angle by iris tissue, have been described as likely causes for glaucoma, and comparable defects have been observed in he...

PURPOSE Psf2 (partner of Sld5 2) represents a member of the GINS (go, ichi, ni, san) heterotetramer [1] and functions in DNA replication as a "sliding clamp." Previous in situ hybridization analyses revealed that Psf2 is expressed during embryonic development in a tissue-specific manner, including the optic cup (retina) and the lens [2]. This article provides an analysis of Psf2 function during...

Immunoprecipitation techniques have shown that characteristic Jens proteins can be found in many tissues of the chick eye. Langman & Prescott (1959), Maisel & Langman (1961o), Maisel (1962) and Maisel & Harmison (1963), among others, have demonstrated antigens cross-reacting with adult chick lens antisera in iris, pigmented retina, cornea and aqueous and vitreous humour. Maisel (1963) suggested...

Inherited glaucoma was exhibited in 55 beagles. The glaucomatous process was divided into early (6 to 12 months of age), moderate (13 to 30 months of age), and advanced (31 months of age). In early glaucoma the tridocorneal angles, as judged by gonioscopy, were open and without anomalies, intraocular pressure was elevated, and the tonographic facility of aqueous outflow was decreased. With mode...