Dementia and glaucoma are both neurodegenerative conditions characterized by neuronal loss leading to cognitive and visual dysfunction, respectively. A variety of evidence exists linking the two diseases including structural signs, specifically degenerative changes within ganglion cells. Both diseases become more prevalent with increased age, but that alone is unlikely to account for the increa...

An increasing number of studies indicate that the optic nerve head of the eye is sensitive not only to changes in intraocular pressure (IOP), but also to intracranial pressure (ICP). This study examines changes to optic nerve and retinal structure in a rat model in response to a range of IOP and ICP levels using optical coherence tomography. Furthermore, we examine the functional sequelae of th...

BACKGROUND Optical coherence tomography (OCT) has become an important tool for diagnosing optic nerve disease. The structural details and reproducibility of OCT continues to improve with further advances in technology. However, artifacts and misinterpretation of OCT can lead to clinical misdiagnosis of diseases if they go unrecognized. EVIDENCE ACQUISITION A literature review using PubMed com...

Introduction: Optic neuropathies are a broad group of diseases in which the dominant disturbance is damage to optic nerve, often irreversible. Underlying causes neuropathy both genetic and environmental. Despite limited treatment options, much research currently being done on substances that could improve nerve function alleviate clinical consequences damage.
 Purpose: This article describ...

PURPOSE To investigate blood flow changes in retinal and optic nerve diseases with Doppler Fourier domain optical coherence tomography (OCT). METHODS Sixty-two participants were divided into five groups: normal, glaucoma, nonarteritic ischemic optic neuropathy (NAION), treated proliferative diabetic retinopathy (PDR), and branch retinal vein occlusion (BRVO). Doppler OCT was used to scan conc...

The ability of a novel intranasally delivered amnion cell derived biologic to suppress inflammation, prevent neuronal damage and preserve neurologic function in the experimental autoimmune encephalomyelitis animal model of multiple sclerosis was assessed. Currently, there are no existing optic nerve treatment methods for disease or trauma that result in permanent vision loss. Demyelinating opti...

Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells (MSCs) have been obtained by several preclinical studies of various ...

ON is an immune‐mediated inflammation of the optic nerve, which could be the initiated symptom of multiple sclerosis (MS) or neuromyelitis optica (NMO). Bilateral simultaneous ON with long enhanced optic nerve lesions in magnetic resonance imaging (MRI) was considered as features of NMO spectrum disorders (NMOSDs). However, comprehensive review of the current literature showed little evidence o...

conclusion the study evaluated the biomechanical properties of the on and peripapillary structures in vivo with swe in glaucoma. we observed stiffer on and peripapillary tissue in glaucomatous eyes, indicating that swe claims new perspectives in the evaluation of on and peripapillary structures in glaucoma disease. background primary open-angle glaucoma is a multifactorial serious disease chara...

Focal destruction of nerve-fibre bundles is one of the pathological common denominators of diseases involving the optic nerve, the optic papilla, or the superficial layer of the retina. Since Bjerrum (i 89 I) and Ronne ( g909, 19 I 3) first identified arcuate defects in the visual field as the perimetric correlates of defects in arcuate nerve fibres of the retina, quantitative perimetric studie...