In a prospective, open-label, currently ongoing study we studied the effects of leptin replacement on b-cell function in 13 patients with congenital or acquired lipodystrophy. Insulin secretory rate (ISR) was calculated by C-peptide deconvolution from plasma glucose and C-peptide levels measured during oral glucose tolerance tests (OGTTs) performed at baseline and after 16–20 weeks of leptin re...

OBJECTIVE This study assessed insulin and glucagon secretion in relation to insulin sensitivity in Caucasian women who develop impaired glucose tolerance (IGT) versus those who maintain normal glucose tolerance (NGT) over a 12-year period. RESEARCH DESIGN AND METHODS At baseline and after 3, 8, and 12 years, glucose tolerance (75-g oral glucose tolerance test), insulin sensitivity (euglycemic...

OBJECTIVE Previously undetected glucose abnormalities are common in patients with acute myocardial infarction (AMI). We evaluated long-term reliability of early glucometabolic classification of patients with AMI by repeated oral glucose tolerance tests (OGTTs). RESEARCH DESIGN AND METHODS A glucometabolic OGTT-based classification was obtained in 122 patients by measuring capillary whole-bloo...

Oral glucose tolerance tests were carried out in 16 clinically normal subjects with pyridoxine deficiency (as adjusted by red cell transaminase activity and the 6h tryptophan load test), and in 16 nondeficient controls. The deficient subjects had fasting normoglycemia with hypoinsulinemia (p less than 0.01), and a normal postglucose increment in insulin, but peak blood glucose and incremental g...

Children with left-to-right shunt, with and without congestive heart failure, were found to have impaired glucose tolerance tests (GTT). In cyanotic children normal levels of glucose were found in association with abnormally high levels of insulin following oral GTT. Several possible mechanisms are proposed to explain the different glucose tolerance alterations: (1) Suppression of insulin relea...

Children with left-to-right shunt, with and without congestive heart failure, were found to have impaired glucose tolerance tests (GTT). In cyanotic children normal levels of glucose were found in association with abnormally high levels of insulin following oral GTT. Several possible mechanisms are proposed to explain the different glucose tolerance alterations: (1) Suppression of insulin relea...

CONTEXT Lysine supplementation may have a positive influence on the regulation of glucose metabolism but it has not been tested in the geriatric population. OBJECTIVE We evaluated the impact of acute lysine supplementation using three randomized experimental scenarios: 1) oral glucose alone (control), 2) oral glucose and low-dose lysine (2 grams), and oral glucose and high dose lysine (5 gram...

Concomitant measurements of plasma insulin levels were performed on all samples of blood obtained from 1,408 patients undergoing a diagnostic oral glucose tolerance test. These patients had no prior diagnosis of diabetes but qualified for the study because of either suspicious history, family history, or signs and symptoms. Graphic display of the findings, with insulin plotted as percent increa...

It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-h glucose level from an oral glucose tolerance test in pregnancy. The 75-g oral glucose tolerance test was carried out at 28 weeks of gestation in 69 participants. A mu...

Six healthy human subjects were studied during three 75-g oral, [13C]glucose tolerance tests to assess the kinetics of dexamethasone-induced impairment of glucose tolerance. On one occasion, they received dexamethasone (4 × 0.5 mg/day) during the previous 2 days. On another occasion, they received a single dose (0.5 mg) of dexamethasone 150 min before ingestion of the glucose load. On the third...