Candida albicans is a commensal yeast that is normally present in the oral cavity of the population. This opportunistic pathogen is frequently isolated from the human mouth but its presence in the oral cavity is not indicative of disease. Colonization of the oral cavity by Candida albicans involves the acquisition and maintenance of a stable yeast population. Micro-organisms are continually bei...

introduction: the efficiency of routine scaling and root planning is negatively influenced by the tooth anatomy and residual bacteria all possibly affecting the treatment outcomes in future. the present study compared the microbiologic effectiveness of the photodynamic therapy (pdt) as an adjunctive treatment modality for nonsurgical treatment in chronic periodontitis. methods: in this randomiz...

Although a broad range of biological and pharmacological activities of apigenin have been reported, the mechanism(s) behind its antibacterial effects are not fully understood. In this study, we investigated the synergistic antibacterial activity of apigenin in combination with existing antimicrobial agents against oral bacteria. The combination effect of apigenin was evaluated against oral bact...

Proteins in human saliva are thought to modulate bacterial colonization of the oral cavity. Yet, information is sparse on how salivary proteins interact with systemic pathogens that transiently or permanently colonize the oral environment. Staphylococcus aureus is a pathogen that frequently colonizes the oral cavity and can cause respiratory disease in hospitalized patients at risk. Here, we in...

Helicobacter pylori (H.pylori) is a gram-negative bacterium that has infected more than half of the world's population. This pathogen colonizes the human gastric mucosa and is usually acquired during childhood. It is an important cause of peptic ulcers, chronic gastritis and stomach cancer. Among the risk factors for acquisition of H. pylori infection, poor socioeconomic status, poor sanitizati...

Significance Two major serotypes of Vibrio cholerae circulate globally and cause pandemic cholera, but how infection or vaccination with each serotype impacts immune responses subsequent protection against future by the pathogen is not well-known. We engineered matched variants a new oral cholera vaccine candidate, HaitiV, to investigate effect variation on immunogenicity protective efficacy. O...

Advances in bacterial genetics came with the discovery of the genetic code, followed by the development of recombinant DNA technologies. Now the field is undergoing a new revolution because of investigators' ability to sequence and assemble complete bacterial genomes. Over 200 genome projects have been completed or are in progress, and the oral microbiology research community has benefited thro...