Absrract. Hemodynamic studies have been performed in 15 male patients with mild to moderately severe essential hypertension. Studies were made after four weeks of placebo treatment and again after acute i.v. administration of propranolol (0.22 mg/kg) and after four weeks of oral propranolol therapy (160-320 mg daily). After acute /3-adrenergic blockade a significant reduction of cardiac index (...

Capillary hemangioma (CH) is the most prevalent benign tumour in children. Most cases showed spontaneous involution without any intervention. However, approximately 10% of all CH patients require treatment. periocular capillary (PCH), especially orbital form, risk significant morbidity; therefore, aggressive treatment needed. Studies a superior outcome systemic propranolol for compared to stand...

The duration of action of single oral doses of 80 and 160 mg of propranolol during acute and sustained therapy was studied in nine patients with stable, exercise-induced angina pectoris. Plasma propranolol levels peaked 2 hours after both doses during acute and sustained therapy, but there were wide variations between individuals in plasma concentration with both dosage schedules. Plasma half-l...

To evaluate the short-term and long-term effectiveness of propranolol and hydrochlorothiazide monotherapy For hypertension, 683 hypertensive men were randomized to treatment with either propranolol or hydrochlorothiazide. Both drugs increased the average fasting plasma glucose level by approximately 5 mg/dl after 10 weeks (p < 0.001) and 1 year (p < 0.001) of treatment, but the elevation persis...

To assess the acute and chronic effects of propranolol on left ventricular wall motion, simultaneous, echo-, apex-, and phonocardiograms were recorded in 10 normal subjects and in 16 patients with ischaemic heart disease, nine with co-ordinate (group A) and seven with incoordinate (group B) contraction in the control site. Records were made after 0.1 mg/kg intravenous or oral therapeutic dose f...

To evaluate the short-term and long-term effectiveness of propranolol and hydrochlorothiazide monotherapy for hypertension, 683 hypertensive men were randomized to treatment with either propranolol or hydrochlorothiazide. Both drugs increased the average fasting plasma glucose level by approximately 5 mg/dl after 10 weeks (p < 0.001) and 1 year (p < 0.001) of treatment, but the elevation persis...

In 31 hypertensive patients the effect of chronic oral administration of the beta blocking agent propranolol on regional cerebral blood flow (rCBF) was studied, using the non-invasive 133Xenon inhalation technique. The results of the measurements were compared to the rCBF obtained in an age-matched normal control group. Our study shows that during long-term therapy with low doses of propranolol...

Propranolol, a nonselective blocker of β-adrenergic receptors, has become the first-line treatment for complicated infantile hemangiomas. Therefore, its use in the pediatric population has expanded in recent years. In adults, β-blockers have been reported to be the most common causative agents for drug-induced psoriasis. In infants treated with propranolol for infantile hemangioma, the onset of...

A random, observer blind, crossover design of study was undertaken in twelve normal male volunteers. Both propranolol (40 mg) and atenolol (50 mg) in single dose oral administration had significantly reduced the heart rate, systolic blood pressure and the value for double product under resting and postexercise conditions compared to the corresponding pretreatment values. Orally administered act...

Immediate hemodynamic effects of beta-adrenergic blockade were determined in six normal subjects and 21 hypertensive patients following intravenous administration of propranolol. Arterial pressure was not reduced, but cardiac output fell by approximately 20% in both groups. Nevertheless, beta-adrenergic inhibition seemed to have different effects in the two groups: Propranolol produced a greate...