Mucoadhesive gels were prepared for the treatment of oral sub mucous fibrosis, which provide effect for extended periods of time. Stress was given for improvised local action of the drug with the addition of mucoadhesive polymer in the formulation. Curcumin was taken as a model drug as it exhibits profound antitumeric & antimutogenic activity. The semisolid preparations comprised of stabilizer ...

BACKGROUND It is generally accepted that the development of cancer in the oral mucosa is preceded by an identifiable non-invasive precursor lesion. The aim of this follow-up study was to estimate the rate and the time to transformation in a group of patients from southern Taiwan with potentially malignant oral epithelial lesions. METHODS The follow-up time is defined as the duration between t...

24 Review Article ORAL SUBMUCOUS FIBROSIS: AN UPDATE ON ETIOLOGY AND PATHOGENESIS-A REVIEW Shukla A, Singh A, Srivastava R Abstract: Oral submucous fibrosis (OSMF) is a chronic disease of oral mucosa characterized by inflammation and progressive fibrosis followed by stiffening of an otherwise yielding mucosa resulting in difficulty in opening the mouth. It is generally accepted today that areca...

This article describes a male patient who presented with trismus due to submucous fibrosis and how in course of time it turned malignant into oral squammous cell carcinoma. Oral submucous fibrosis (OSF) is a chronic, complex, irreversible, highly potent pre-cancerous condition characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues (lamina prop...