this work described a simple and efficient synthesis of dialkyl 3-(alkylamino)-1-aryl-1h-pyrazole-4,5-dicarboxylates via a three component reaction between arylhydrazine, alkylisocyanid and dialkylacetylenedicarboxylates in the presence of phenylisocyanate and α-fe2o3 nanoparticles. eco friendly, solvent-free conditions, excellent yields, and short reaction times, inexpensive and readily availa...

Unfortunately, many toxic solvents are used in chemistry laboratories and the manufacturing of materials, which poses a serious risk to process safety, natural environment, human health. In this review, different tools for solvent-free organic reactions have been surveyed as an approach green chemistry, where known upset our ecosystems so enormous research effort has exerted during last decade ...

AcrAB-TolC is a major efflux pump in Escherichia coli. It was reported that tolC is overexpressed and involves in improving the organic solvent tolerance level in Escherichia coli marR mutants that are resistant to several antibiotics, such as ciprofloxacin. Low and intermediate levels resistance did not improve organic solvent tolerance. Thus, in this descriptive-experimental study it was deci...

Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and ...

conclusions in this study, we isolated b. licheniformis producing an organic solvent-stable protease from oil-contaminated soil. the protease was stable and active in various organic solvents. by purification, the protease could be used as a biocatalyst for organic solvent-based enzymatic synthesis. results according to 16srdna sequencing, strain isa9 was identified as a new strain of bacillus ...

We report the successful preparation of solvent-free metal nanoparticle (NP) fluids with multiple-functionalities, such as rheological properties, magnetism, ionic conductivity, and electrical properties, allowing for facile synthesis and mass production. The gold nanoparticles (AuNPs) used in this study were synthesized using tetraoctylammonium bromide (TOABr) in toluene and then directly phas...