Drug repositioning is an important component of therapeutic stratification in the precision medicine paradigm. Molecular profiling and more sophisticated analysis of longitudinal clinical data are refining definitions of human diseases, creating needs and opportunities to re-target or reposition approved drugs for alternative indications. Drug repositioning studies have demonstrated success in ...

Dilaceration is one of the causes of maxillary central incisor eruption failure. Surgical excision is frequently the first choice of treatment for a severely dilacerated incisor. In this article, the case of a horizontally impacted and dilacerated maxillary central incisor was diagnosed and treated by surgical exposure using the apically repositioned flap technique combined with orthodontic tra...

OBJECTIVE To explore the early dental interventional strategies for adolescent patients and a child patient with cleidocranial dysplasia (CCD). METHODS Surgical exposure using the apically repositioned flap technique combined with orthodontic traction was used in the adolescent patients whose ideal treatment time for initiating treatment was missed. For the child patient whose ideal treatment...

Intraosseous migration of unerupted teeth across the midline is a rare phenomenon known as dental transmigration. The term transmigration was coined by Ando et al in 1964. Transmigration defined movement canine through Tarsitano al. involving commonly called because affected moves mesially mandibular symphysis to opposite side mandible. Impaction maxillary canines more prevalent, whereas seen m...

statement of problem: snoring is the most common sleep disorder which in itself may only be viewed as an obnoxious disturbance in human society; however it must be considered a potential indicator of significant medical problems such as: hypertension, obstructive sleep apnea, cerebrovascular infarction and ischemic heart disease. purpose: the purpose of this study was to evaluate the effectiven...

INTRODUCTION Extrusive luxation is a traumatic dental injury caused by the action of oblique forces, characterized by partial displacement of the tooth out of its socket. The ideal treatment for this type of trauma involves repositioning the tooth in its socket. However, in cases where the tooth cannot be repositioned, different options may be considered, such as intentional reattachment and or...

Abstract Introduction Maxillary incisors have a significant role on the facial aesthetics of an individual. Following trauma to primary dentition, maxillary are vulnerable eruption failure and occasionally root dilaceration. These teeth can be challenging treat. Discussion This case report demonstrates complex management 10-year-old male who presented with severely displaced unerupted central i...

[Purpose] The purpose of this study was to identify the effects of kinesiology taping on repositioning error of the knee joint after quadriceps muscle fatigue. [Subjects] Thirty healthy adults with no orthopaedic or neurological problems participated in this study. [Methods] The repositioning error of the knee joint was measured using a digital goniometer when the subjects extended their domina...