Background: The use of a bone graft in regeneration is challenging. Tooth material has been used as alternative due to its similar composition organic and inorganic materials close the bone. Recently, nanotechnology improve quality. osteoconduction rate defect area represents Purpose: This study aimed compare number osteoblasts using nano-tooth grafts micro-tooth Wistar rats. Methods: rats were...

The development of treatment strategies for improving secondary stability at the bone-implant interface is a challenge. Porous implants are one solution long-term implant stability, but osteoconduction process into bone can be slow. Strain-driven osteogenesis from mechanostat theory offers insight pathways post-operative mechanisms to deliver strain need refinement. In this work, use therapeuti...

Hydroxyapatite (HAp), a main constituent of the cortical bone, retains large surface charge that plays critical role in regeneration bones, whose source remains an enigma. Here, we used multi-eigenmode piezoresponse force microscopy via Pearson correlation and conducted multiscale material analysis to independently measure piezoelectric coefficient density HAp. Quantitative comparison was betwe...

Bone repair using BMP-2 is a promising therapeutic approach in clinical practices, however, high dosages required to be effective pose issues of cost and safety. The present study explores the potential low dose treatment via tissue engineering approach, which amalgamates 3-D macro/microporous-nanofibrous bacterial cellulose (mNBC) scaffolds primed murine mesenchymal stem cells (C3H10T1/2 cells...

We have developed a new drug delivery system using porous apatite-wollastonite glass ceramic (A-W GC) to treat osteomyelitis. A-W GC (porosity, 70% and 20% to 30%), or porous hydroxyapatite (HA) blocks (porosity 35% to 48%) used as controls, were soaked in mixtures of two antibiotics, isepamicin sulphate (ISP) and cefmetazole (CMZ) under high vacuum. We evaluated the release concentrations of t...

The authors describe a new material termed mineralized plasmatic matrix (MPM), a combination of platelets, fibrin concentrate, and autogenous bone to repair alveolar cleft defects. Autogenous cancellous bone is widely used to this end because such bone affords the functionalities (osteogenesis, osteoinduction, and osteoconduction) required for successful outcomes. To optimize these features, au...

The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (...

Different types of bone-graft substitutes have been developed, and are on the market worldwide to eliminate the drawbacks of autogenous grafting. They vary in composition, strength, osteoinductive and osteoconductive properties, mechanism and rates at which they are resorbed and remodelled. Of these, THA is a novel material produced by one of us (FNO). This study was performed to determine the ...

Alveolar atrophy following tooth extraction remains a challenge for future dental implant placement. Immediate implant placement and postextraction alveolar preservation are two methods that are used to prevent significant postextraction bone loss. The purpose of this study is to investigate the usefulness of hydroxyapatite / beta tricalcium phosphate (HA/BTCP) with hyaluronic acid (HY) for alv...