نتایج جستجو برای: ovarian development

تعداد نتایج: 1489267  

2012
Sreeja Sarojini Ayala Tamir Heejin Lim Shihong Li Shifang Zhang Andre Goy Andrew Pecora K. Stephen Suh

Despite the widespread use of conventional and contemporary methods to detect ovarian cancer development, ovarian cancer remains a common and commonly fatal gynecological malignancy. The identification and validation of early detection biomarkers highly specific to ovarian cancer, which would permit development of minimally invasive screening methods for detecting early onset of the disease, ar...

2009
Shannon French Luisa Rodriguez Alan Schlesinger Laurence McCullough Jennifer Dietrich John Hicks Lefkothea Karaviti

Three infants with ambiguous genitalia and suspected ovotestes were given recombinant FSH to induce ovarian follicular development. The development of follicles in the gonadal tissue suggested the presence of ovarian tissue in two of the three infants. This method may provide a means to better characterize gonadal anatomy in patients affected by disorders of sex development (DSD). Sonographic i...

Journal: :anatomical sciences journal 0
mahmoud moghaddam-dorafshani medi jalali mohammad reza nikravesh ali reza ebrahimzadeh

introduction: among the endocrine diseases, hypothyroidism is the commonest after diabetes.thyroid hormones (t3,t4) are essential for genital organs function. apoptosis process in ovarian cells plays a significant role of development in ovarian follicles. the aim of the present study was determine the apoptotic index induced by hypothyroidism in rat ovarian follicles. materials and methods: in ...

2016
Hsun-Ming Chang Jie Qiao Peter C.K. Leung

BACKGROUND Initially identified for their capability to induce heterotopic bone formation, bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor β superfamily. Using cellular and molecular genetic approaches, recent studies have implicated intra-ovarian BMPs as potent regulators of ovarian follicular function. The bi-directional comm...

Journal: :Journal of the National Cancer Institute 1996
K J Helzlsouer A J Alberg E P Norkus J S Morris S C Hoffman G W Comstock

BACKGROUND Antioxidant micronutrients, such as alpha-tocopherol (vitamin E), the carotenoids, and selenium, may protect against the development of cancer by preventing free radical damage at the cellular level. PURPOSE A nested case--control study was conducted among donors to a serum bank to examine the association between levels of serum micronutrients and/or cholesterol and the development...

Journal: :Reproductive biology and endocrinology : RB&E 2003
Dusica Cvetkovic

Ovarian cancer represents the most lethal of the gynecological neoplasms. The molecular and genetic events associated with early ovarian oncogenesis are still largely unknown, thus contributing to the lack of reliable biomarkers for disease detection. Since the majority of ovarian tumors are diagnosed at an advanced stage, the availability of early ovarian cancer tissue samples for molecular an...

2015
Ying Li Ying Fang Ying Liu Xiaokui Yang

MicroRNAs (miRNAs) are endogenous, small, noncoding single-stranded RNA molecules approximately 22 nucleotides in length. miRNAs are involved in the post-transcriptional regulation of various important cellular physiological and pathological processes, including cell proliferation, differentiation, apoptosis, and hormone biosynthesis and secretion. Ovarian follicles are the key functional units...

2016
Hanyu Ma Tian Tian Shuang Liang Xubin Liu Hongwei Shen Meng Xia Xingyang Liu Wenhui Zhang Liantang Wang Shangwu Chen Li Yu

Estrogen signaling influences the development and progression of ovarian tumors, but the underlying mechanisms are not well understood. In a previous study we demonstrated that impairment of estrogen receptor alpha (ERα)-mediated olfactomedin 4 (OLFM4) expression promotes the malignant progression of endometrioid adenocarcinoma, and we identified OLFM4 as a potential target of miR-486-5p. In th...

2015
Kathy Qi Cai Ying Wang Elizabeth R. Smith Jennifer L. Smedberg Dong-Hua Yang Wan-Lin Yang Xiang-Xi Xu

White spotting variant (Wv) mice are spontaneous mutants attributed to a point mutation in the c-Kit gene, which reduces the tyrosine kinase activity to around 1% and affects the development of melanocytes, mast cells, and germ cells. Homozygous mutant mice are sterile but can live nearly a normal life span. The female Wv mice have a greatly reduced ovarian germ cell and follicle reserve at bir...

2012
Eleonora Petrucci Luca Pasquini Manuela Bernabei Ernestina Saulle Mauro Biffoni Fabio Accarpio Simone Sibio Angelo Di Giorgio Violante Di Donato Assunta Casorelli Pierluigi Benedetti-Panici Ugo Testa

BACKGROUND Ovarian cancer remains a leading cause of death in women and development of new therapies is essential. Second mitochondria derived activator of caspase (SMAC) has been described to sensitize for apoptosis. We have explored the pro-apoptotic activity of LBW242, a mimic of SMAC/DIABLO, on ovarian cancer cell lines (A2780 cells and its chemoresistant derivative A2780/ADR, SKOV3 and HEY...

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