Anti-NMDAR (N-methyl-D-aspartate receptor) encephalitis is an immune-mediated encephalitis. It has been predominantly described in young women and is commonly associated with an ovarian teratoma. We report a case of anti-NMDAR encephalitis associated with a 7 mm ovarian teratoma that was completely resected by laparoscopic surgery. An 18-year-old woman suddenly presented with personality change...

Cancer treatments can often adversely affect the quality of life young women. One most relevant negative impacts is loss fertility. Cyclophosphamide one detrimental chemotherapeutic drugs for ovary. may induce destruction dormant follicles while promoting follicle activation and growth. Herein, we demonstrate in vivo protective effect allosteric Bcr-Abl tyrosine kinase inhibitor Asciminib on si...

Females are born with a finite number of oocytes, collectively termed the ovarian reserve, established within developing fetal ovary. Consequently, maternal exposure to reproductive toxicants can have harmful effects on future fertility her unborn female fetus. The chemical benzo[a]pyrene (B[a]P) is prominent component cigarette smoke. Despite it being known ovotoxicant, around 8% women in Euro...

Gonadal dysfunction and infertility are major endocrinological late effects among childhood cancer survivors. Chemotherapy and radiation have gonadotoxic effects and diminish the ovarian reserve. The serum concentration of anti-Müllerian hormone (AMH) is a useful marker of ovarian reserve in survivors. We conducted a longitudinal study to investigate the variations of AMH in evaluating the acut...

Success of any assisted reproductive technology is dependent on selection of correct stimulation protocol. This is based on prestimulation assessment of female to assess ovarian response and reserve. But, this assessment can also be done by ultrasound scan on 2nd to 3rd day of menstrual cycle, named as ‘baseline scan’. This scan is done to categorize ovary into one of the four types: Normal ova...

BACKGROUND The human ovary contains a fixed number of primordial follicles that decreases bi-exponentially with age, culminating in the menopause at an average age of 50-51 years. There currently is no reliable test of ovarian reserve for individual women that will accurately predict their remaining reproductive lifespan. METHODS AND RESULTS We use the Faddy-Gosden model of human primordial f...

In this issue, Dr Tilly’s laboratory presents another challenge to a half century– old dogma that ovarian reserve, made up of primordial follicles, cannot be replenished after birth. Their earlier work indicated that egg manufacturing continued into adult life in mice and that germ stem cells could have originated from the bone marrow; this work was met with much skepticism. It has been known f...

Objective To compare serum anti-Müllerian hormone (AMH) and other endocrine parameters between patients diagnosed with polycystic ovary syndrome (PCOS) and age-matched ovulatory women. Materials and methods AMH, DHEAS, FSH, LH, PRL, TSH and total testosterone (TT) were prospectively measured in oligo-ovulatory PCOS patients (n = 595) and in ovulatory non-PCOS women (n = 157) referred to a ter...