We present a case of acute tolterodine overdose with anticholinergic toxidrome including drowsiness, confusion and pyrexia. Tolterodine was commonly used in recent years for the treatment of overactive bladder syndrome. Experience with acute tolterodine poisoning was limited. The pharmacology, clinical use and side effects of tolterodine were reviewed. The clinical manifestations, toxicology an...

INTRODUCTION Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood psychiatric disorder. This disorder is more prevalent in some chronic diseases. OBJECTIVES To investigate ADHD in children with overactive bladder. PATIENTS AND METHODS A number of 92 children with overactive bladder and 92 healthy children without overactive bladder (age range of both groups 5 to 12 y...

PURPOSE We validated a new 7-item overactive bladder symptom score. MATERIALS AND METHODS Normal subjects and consecutive patients with lower urinary tract symptoms with or without overactive bladder were recruited and classified into 3 groups based on their response to the question on an intake questionnaire, "Do you ever experience a sudden urge to urinate that makes you want to stop what y...

Overactive bladder (OAB) is a symptomatic complex affecting both men and women. The overall incidence is above 10% but may exceed 40% in the elderly population (Irwin et al., 2006; Irwin et al., 2009; Sexton et al., 2009a). OAB is defined by the International Continence Society (ICS) as a clinical syndrome characterized by urinary urgency, with or without incontinence, usually with frequency an...

Overactive bladder syndrome (OAB) is a lifestyle disease and its incidence increases with age. Although it is not a life-threatening disease, it is known to have a significant impact on the quality of life. The first-choice pharmacological treatment of OAB is antimuscarinics. However, their limited clinical effectiveness and unsatisfactory tolerance profile, combined with the advancement of kno...

PURPOSE A recent study demonstrated improvement in nocturnal urgency in patients with overactive bladder when treated with fesoterodine. In the current study we aimed to determine which bladder diary parameters predict the response to fesoterodine in these patients. MATERIALS AND METHODS Patients with nocturnal urgency completed a 2-week, single-blind placebo run-in followed by 1:1 double-bli...