This review is devoted to the problems of common features linking metabolic disorders and type 2 diabetes with development Alzheimer’s disease. The pathogenesis disease closely intersects mechanisms development, an important risk factor for both pathologies aging. Common pathological include factors in oxidative stress, neuroinflammation, insulin resistance, amyloidosis, as well impaired mitoch...

Intrauterine hypoxia associated with oxidative stress represents an important risk factor for development of neurobehavioral dysfunctions. In the present study, we investigated the potential protective effect of melatonin (MEL) on neurobehavioral dysfunctions induced by chronic intrauterine hypoxia in rats by the anticonvulsant drug phenytoin (PHT), which is known by its teratogenic potential. ...

The protein folding capabilities in the endoplasmic reticulum (ER) are disturbed by alternations in the cellular homeostasis such as the disruption of calcium ion homeostasis, the expression of mutated proteins and oxidative stress. In response to these ER dysfunctions, eukaryotic cells activate canonical branches of signal transduction cascades to restore the protein folding capacity and avoid...

About 3000 tons of beans are not used in human food due to hardening. Several studies on bean-derived bioactive peptides have shown potential treat some diseases, including those relying oxidative dysfunctions. We assessed the effects extracted from hardened bean Phaseolus vulgaris (PV) reactive oxygen species (ROS) and nitric oxide (NO) production, cytotoxic cytoprotective endothelial cells, o...

Cadmium (Cd), a widely existed environmental contaminant, was shown to trigger neurotoxicity by regulating autophagy, ion homeostasis and redox. Lycopene (LYC) is a natural substance with potent antioxidant capacity. Nevertheless, little is known about i) the relationship of Cd-induced neurotoxicity and autophagy, ion homeostasis as well as redox in the hippocampus; ii) the role of LYC in the r...

The 2014 Workshop on Algorithms for Modern Massive Data Sets (MMDS 2014) will address algorithmic and statistical challenges in modern large-scale data analysis. The goals of MMDS 2014 are to explore novel techniques for modeling and analyzing massive, high-dimensional, and nonlinearly-structured scientific and internet data sets; and to bring together computer scientists, statisticians, mathem...

There is often an imbalance between the intake of n-6 and n-3 polyunsaturated fatty acids in patients with inflammatory and autoimmune diseases. Oxidative damage and the production of reactive oxygen species by various immune cells follow during the ageing process. Caloric restriction induces a transcriptional response of the genes known to inhibit oxidative stress, tumourigenesis, splicing mRN...