نتایج جستجو برای: p15ink4b gene
تعداد نتایج: 1141459 فیلتر نتایج به سال:
Nuclear reprogramming enables patient-specific derivation of induced pluripotent stem (iPS) cells from adult tissue. Yet, iPS generation from patients with type 2 diabetes (T2D) has not been demonstrated. Here, we report reproducible iPS derivation of epidermal keratinocytes (HK) from elderly T2D patients. Transduced with human OCT4, SOX2, KLF4 and c-MYC stemness factors under serum-free and fe...
PURPOSE Aberrant methylation of 5' gene promoter regions is an epigenetic phenomenon that is a major mechanism for silencing of tumor suppressor genes in many cancer types. There is limited information about the molecular changes involved in the pathogenesis of gallbladder carcinoma (GBC), including methylation status. EXPERIMENTAL DESIGN We investigated the aberrant promoter methylation prof...
The multi tumor suppressor genes MTS1 (CDKN2, p16INK4A) and MTS2 (CDKN1, p15INK4B) located at 9p21-22 are inactivated in some human cancers via several mechanisms including deletion and hypermethylation. In hematological malignancies, deletion of p16/p15 locus has been shown to be highly specific to lymphoid malignancies, and more particularly to T-cell acute lymphoblastic leukemia (TALL). We h...
Background: One of the acute hematologic malignancies is promyelocytic leukemia (APL) that resulted in translocation chromosomes 15 and 17, t (15; 17), cessation maturation myeloid cell line, ultimate aggregation neoplastic promyelocytes. Regarding appetence using herbal marine medicine studies increasing, on other hand, features Cassiopea andromeda Venom remained unclear; this study was conduc...
Within the tumor suppressor protein INK4 ~inhibitor of cyclin-dependent kinase 4! family, p15INK4B is the smallest and the only one whose structure has not been determined previously, probably due to the protein’s conformational flexibility and instability. In this work, multidimensional NMR studies were performed on this protein. The first tertiary structure was built by comparative modeling w...
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