Stereoelectroencephalography (SEEG) signals can be obtained by implanting deep intracranial electrodes. SEEG depth electrodes record brain activity from the shallow cortical layer and structures, which is not achievable through other recording techniques. Moreover, has advantage of a high signal-to-noise ratio (SNR). Therefore, it provides potential way to establish highly efficient brain-compu...

E1A binding protein (p300) and its paralog CREB (CBP or CREBBP) are ubiquitously expressed histone acetyl transferases (HAT) that act by scaffolding as co-activator enhancer of different transcription factors like HIF1a, BRCA-1, p53, c-Myc, Estrogen receptor (ER) Androgen (AR). CBP p300 multidomain proteins harbour functional units imperative for chromatin remodelling Bromodomain (BD), Histone ...

The Concealed Information Test (CIT) uses psychophysiological measures to determine the presence or absence of crime-related information in a suspect's memory. We conducted a meta-analysis on the validity of the CIT based on four physiological measures-skin conductance response (SCR), respiration line length (RLL), changes in heart rate (HR), and enhanced amplitudes of the P300 component of the...

The P300 event-related brain potential (ERP) was elicited with auditory and visual stimuli from members of 13 families who were at high risk (HR) for alcoholism (father diagnosed as alcoholic) and 13 families at low risk (LR) for alcoholism. Each family consisted of a father, mother, and at least two biological children. The intrafamily member correlations (father vs. child, mother vs. child, c...

The objective of this study was to perform a systematic review regarding the effects of transcranial magnetic stimulation (TMS) on the cognitive event-related potential P300. A search was performed of the PubMed database, using the keywords "transcranial magnetic stimulation" and "P300." Eight articles were selected and, after analysis of references, one additional article was added to the list...

P300 event-related brain potential (ERP) measures are affected by target stimulus probability, the number of nontargets preceding the target in the stimulus sequence structure, and interstimulus interval (ISI). Each of these factors contributes to the target-to-target interval (TTI), which also has been found to affect P300. The present study employed a variant of the oddball paradigm and manip...

The amplitude of the P300 event-related potential (ERP) has been reported to be reduced over left compared to right temporal sites in schizophrenia patients. This left temporal P300 reduction has been associated with positive symptom severity and gray matter reduction in the left superior temporal gyrus. We investigated a group of patients with a first episode of schizophrenia spectrum psychosi...

Prior work has consistently revealed a relationship between antisocial behavior and reduced P300 amplitude. Fewer studies have directly evaluated behavioral indices of aggression and P300, and those that have generally do not account for potential mediating variables such as age, intelligence, and behavioral task performance. The current study assessed the relationship between the total number ...

Obesity and type 2 diabetes are associated with increased lipogenesis in the liver. This results in fat accumulation in hepatocytes, a condition known as hepatic steatosis, which is a form of nonalcoholic fatty liver disease (NAFLD), the most common cause of liver dysfunction in the United States. Carbohydrate-responsive element-binding protein (ChREBP), a transcriptional activator of glycolyti...

OBJECTIVE Studies exploring chronic alcoholism with event-related potentials (ERPs) have shown delayed latency and reduced amplitude of the P300, a long-lasting positive potential reflecting decisional processing. This P300 deficit in alcoholism is generally interpreted as a disturbance in central nervous system inhibition or in memory/attention. The present study aimed at identifying if this e...